New drug tested to tame overactive liver disease
NCT ID NCT05569759
Summary
This study tested whether adding an experimental drug called zetomipzomib to standard steroid treatment could better control autoimmune hepatitis. It involved 24 adults whose liver disease was still active despite standard care. Participants received either the new drug or a placebo injection weekly for 24 weeks, alongside their regular steroids, to see if it improved their liver tests and allowed them to reduce steroid doses.
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Contacts and locations
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Locations
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Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
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California Pacific Medical Center
San Francisco, California, 94109, United States
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Indiana University
Indianapolis, Indiana, 46202, United States
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Keck School of Medicine of USC
Los Angeles, California, 90033, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Mayo Clinic Arizona
Phoenix, Arizona, 85054, United States
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Mayo Clinic Florida
Jacksonville, Florida, 32224, United States
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New York University Langone Health/Grossman School of Medicine
New York, New York, 10016, United States
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Northwell Health Center for Liver Disease and Transplantation
Manhasset, New York, 11030, United States
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Northwestern University
Chicago, Illinois, 60611, United States
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Ochsner Clinic Foundation
New Orleans, Louisiana, 70121, United States
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Rush University
Chicago, Illinois, 60612, United States
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Stanford Medicine
Redwood City, California, 94063, United States
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University Hospitals Cleveland Medical Center
Cleveland, Ohio, 44106, United States
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University of California, Los Angeles
Los Angeles, California, 90095, United States
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University of California, San Francisco
San Francisco, California, 94132, United States
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University of Colorado
Aurora, Colorado, 80045, United States
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University of Miami
Miami, Florida, 33136, United States
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University of Michigan Medical Center
Ann Arbor, Michigan, 48109, United States
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University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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Virginia Commonwealth University
Richmond, Virginia, 23298, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
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Yale University
New Haven, Connecticut, 06510, United States
Conditions
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