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Sound sleep: could a simple noise improve memory in schizophrenia?

NCT ID NCT04783571

Knowledge-focused Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study explores whether playing quiet sounds during a nap can help normalize brain activity and improve memory in people with schizophrenia. Researchers will compare memory and sleep patterns in 70 participants (healthy controls and schizophrenia patients) under two conditions: with and without auditory stimulation. The goal is to see if this simple, non-invasive approach can enhance sleep-related memory consolidation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
auditory stimulation (quiet sounds played during sleep)
What this could lead to
If it works, this could point toward a simple, non-drug way to improve memory in schizophrenia.
What could go wrong
This is a small, early-stage study with only 70 participants. The effects may be small or not work at all, and results may not apply to everyone with schizophrenia.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 70 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2020

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: For healthy controls: * Male and female subjects * 18-50 years of age * Proficient in English For schizophrenia patients: * Male and female schizophrenia outpatients * 18-50 years of age * Proficient in English * Able to give informed consent Exclusion Criteria: * Pregnant females * Current use of psychotropic medications (healthy controls only) * A history of head injury resulting in prolonged loss of consciousness or other neurological sequelae * IQ \<85 * Neurological disorder (including seizure disorder) * Significant hearing or vision loss * Current substance abuse or dependence (nicotine abuse or dependence is not exclusionary) * Any unstable chronic medical condition that affects sleep * Diagnosed sleep disorder

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Conditions

The condition(s) this trial relates to.

schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Schizophrenia

Contacts and locations

Locations

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.