Light-Activated drug combo shows promise in head and neck cancer trial
NCT ID NCT06699212
First seen Nov 01, 2025 · Last updated May 23, 2026 · Updated 31 times
Summary
This phase 3 trial tests whether a new light-activated therapy (ASP-1929 photoimmunotherapy) combined with the immunotherapy drug pembrolizumab helps people with recurrent head and neck cancer live longer compared to standard treatments. About 412 adults whose cancer has returned but not spread to other organs will be randomly assigned to receive either the new combination or standard care (pembrolizumab alone or with chemotherapy). The study aims to see if the combination improves overall survival.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Locations
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Aichi Cancer Center
RECRUITINGAichi, 464-8681, Japan
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Avera Cancer Institute
RECRUITINGSioux Falls, South Dakota, 57105, United States
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Chi Mei Hospital
RECRUITINGTainan, 736402, Taiwan
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China Medical University
RECRUITINGTaichung, 404327, Taiwan
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City of Hope
RECRUITINGDuarte, California, 91010, United States
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Hiroshima University Hospital
RECRUITINGHiroshima, 734-8551, Japan
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Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITINGKaohsiung City, 807377, Taiwan
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Kyoto Prefectural University of Medicine
RECRUITINGKyoto, 602-8566, Japan
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Linkou Chang Gung Memorial Hospital
RECRUITINGTaoyuan City, 333423, Taiwan
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MacKay Memorial Hospital
RECRUITINGTaipei, 104217, Taiwan
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National Taiwan University Hospital
RECRUITINGTaipei, 100225, Taiwan
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Rhode Island Hospital
RECRUITINGProvidence, Rhode Island, 02903, United States
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Taichung Veterans General Hospital
RECRUITINGTaichung, 407219, Taiwan
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Taipei Municipal Wanfang Hospital
RECRUITINGTaipei, 116081, Taiwan
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Taipei Veterans General Hospital
RECRUITINGTaipei, 112201, Taiwan
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Tampa General Hospital
RECRUITINGTampa, Florida, 33606, United States
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Thomas Jefferson University, Sidney Kimmel Cancer Center
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
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Tokyo Medical University Hospital
RECRUITINGTokyo, 160-0023, Japan
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Tottori University Hospital
RECRUITINGYonago, 683-8504, Japan
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University of Kentucky Medical Center
WITHDRAWNLexington, Kentucky, 40536, United States
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University of Miami
RECRUITINGMiami, Florida, 33136, United States
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University of Texas, MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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Conditions
Explore the condition pages connected to this study.