Herbal boost? ashwagandha may improve brain function in schizophrenia
NCT ID NCT07541157
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether adding ashwagandha, an herbal supplement, to standard schizophrenia medication (risperidone) could improve thinking and memory. 80 men with schizophrenia took either risperidone alone or risperidone plus ashwagandha for 8 weeks. Researchers measured changes in a brain chemical (BDNF) and cognitive test scores to see if the combination worked better.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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80 people
The number who actually took part.
- Started
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Sep 2025
- Finished
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Jan 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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20 to 45 years
- Sex
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Male participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Male patients diagnosed with schizophrenia based on ICD-10/PPDGJ III criteria * Aged 20-45 years * Duration of illness ≤ 5 years * Patients who have passed the acute phase (PANSS-EC \< 15) * Receiving risperidone 4 mg/day * Willing to participate and provide written informed consent Exclusion Criteria: * Presence of organic comorbid diseases * History of substance abuse (NAPZA) within the last 1 year, except caffeine and nicotine * Use of anti-inflammatory drugs, antibiotics, or antioxidant agents * Intellectual disability (mental retardation)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Dadi Psychiatric Hospital (RSJ Dadi) Makassar
Makassar, South Sulawesi, 90245, Indonesia
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Other studies related to the condition(s) this trial covers.