Lung cancer radiation study pulled before it even started
NCT ID NCT05488626
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study aimed to see if a newer, daily-adaptive radiation technique could reduce coughing, breathing trouble, and swallowing pain in people with stage III non-small cell lung cancer getting chemo and radiation. It planned to compare the adaptive method to standard radiation. However, the trial was withdrawn before enrolling any participants, so no results are available.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Started
-
Oct 2022
- Expected to finish
-
Dec 2028
An estimate. End dates often move.
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Provision of signed and dated informed consent form. 2. Histologically confirmed NSCLC 3. Clinical stage IIIA-IIIB (AJCC v8) disease who are either: 1. Patients classified as non-operable by the treatment team 2. Patients who refuse surgery 4. Clinical stage IIIC due to contralateral mediastinal lymph node involvement only (e.g., no contralateral hilar or any supraclavicular/cervical lymph node metastases). Mediastinal stations 2R and 4R are considered contralateral for patients whose primary tumor is within the left lung. Mediastinal stations 2L, 4L, 5, and 6 are considered contralateral for patients whose primary tumor is in the right lung. 5. Completed evaluation for metastatic disease with no distant metastases identified. Evaluation must include the following: 1. History and physical examination within 30 days prior to enrollment. 2. Whole body FDG PET-CT for staging within 60 days prior to enrollment 3. Brain MRI or contrast enhanced CT within 60 days prior to enrollment. 6. ECOG performance status 0-2 and deemed clinically fit for chemoradiotherapy. 7. Age ≥18 years (or at least the local age of consent) 8. Patients must have normal organ and marrow function. 9. Serum creatinine ≤1.5 mg/dL within 60 days prior to enrollment. 10. Measurable disease must be present. 11. Negative urine or serum pregnancy test within 14 days prior to enrollment for women of childbearing potential. Exclusion Criteria: 1. Contralateral hilar or any supraclavicular/cervical lymph nodes. 2. Baseline grade ≥3 dyspnea, or cough, or dysphagia. 3. Prior invasive non-skin malignancy unless disease free for a minimum of 3 years. 4. History of prior RT to the thorax. 5. Severe imaging artifact that, in the view of the local investigator, would preclude accurate identification of the thoracic anatomy and tumor targets on the cone beam CT (e.g., artifact created implanted cardiac device in proximity to the targets). 6. Evidence of malignant pleural effusion, defined as either FDG PET avidity within effusion fluid or presence of malignant cells identified by cytology of thoracentesis fluid. 7. Severe active chronic obstructive pulmonary disease or respiratory illness other than NSCLC precluding study therapy. 8. Hospitalization for chronic obstructive pulmonary disease or respiratory illness other than NSCLC within 1 year prior to study enrollment. 9. Women of childbearing potential and sexually active women not willing or able to use contraception.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Stage III non-small cell lung cancer are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Alabama at Birmingham
Birmingham, Alabama, 35294, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Glowing drug reveals why lung cancer immunotherapy fails
- Gene-Hacked immune cells take on tough cancers
- Thymus gland may hold key to preventing immune cell loss during lung cancer treatment
- New combo therapy shows promise for tough lung cancer
- New lung cancer combo aims to boost treatment completion
- Blood test may personalize lung cancer therapy