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Lung cancer radiation study pulled before it even started

NCT ID NCT05488626

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aimed to see if a newer, daily-adaptive radiation technique could reduce coughing, breathing trouble, and swallowing pain in people with stage III non-small cell lung cancer getting chemo and radiation. It planned to compare the adaptive method to standard radiation. However, the trial was withdrawn before enrolling any participants, so no results are available.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Started

Oct 2022

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Provision of signed and dated informed consent form. 2. Histologically confirmed NSCLC 3. Clinical stage IIIA-IIIB (AJCC v8) disease who are either: 1. Patients classified as non-operable by the treatment team 2. Patients who refuse surgery 4. Clinical stage IIIC due to contralateral mediastinal lymph node involvement only (e.g., no contralateral hilar or any supraclavicular/cervical lymph node metastases). Mediastinal stations 2R and 4R are considered contralateral for patients whose primary tumor is within the left lung. Mediastinal stations 2L, 4L, 5, and 6 are considered contralateral for patients whose primary tumor is in the right lung. 5. Completed evaluation for metastatic disease with no distant metastases identified. Evaluation must include the following: 1. History and physical examination within 30 days prior to enrollment. 2. Whole body FDG PET-CT for staging within 60 days prior to enrollment 3. Brain MRI or contrast enhanced CT within 60 days prior to enrollment. 6. ECOG performance status 0-2 and deemed clinically fit for chemoradiotherapy. 7. Age ≥18 years (or at least the local age of consent) 8. Patients must have normal organ and marrow function. 9. Serum creatinine ≤1.5 mg/dL within 60 days prior to enrollment. 10. Measurable disease must be present. 11. Negative urine or serum pregnancy test within 14 days prior to enrollment for women of childbearing potential. Exclusion Criteria: 1. Contralateral hilar or any supraclavicular/cervical lymph nodes. 2. Baseline grade ≥3 dyspnea, or cough, or dysphagia. 3. Prior invasive non-skin malignancy unless disease free for a minimum of 3 years. 4. History of prior RT to the thorax. 5. Severe imaging artifact that, in the view of the local investigator, would preclude accurate identification of the thoracic anatomy and tumor targets on the cone beam CT (e.g., artifact created implanted cardiac device in proximity to the targets). 6. Evidence of malignant pleural effusion, defined as either FDG PET avidity within effusion fluid or presence of malignant cells identified by cytology of thoracentesis fluid. 7. Severe active chronic obstructive pulmonary disease or respiratory illness other than NSCLC precluding study therapy. 8. Hospitalization for chronic obstructive pulmonary disease or respiratory illness other than NSCLC within 1 year prior to study enrollment. 9. Women of childbearing potential and sexually active women not willing or able to use contraception.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35294, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.