Prebiotic powder shows promise for curbing hunger
NCT ID NCT06884449
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed study tested whether a prebiotic supplement called Arrabina can help healthy adults feel fuller and less hungry. 135 participants took either a low or high dose of Arrabina or a placebo powder for 12 weeks. Researchers measured appetite sensations like hunger and fullness after a standard breakfast to see if the supplement made a difference.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Arrabina (a prebiotic dietary supplement)
- What this could lead to
- If it works, this could point toward a natural supplement to help manage appetite and support weight control.
- What could go wrong
- This is a small, early-stage trial in healthy adults, not a disease population. The effects may be modest or not translate to real-world weight loss.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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135 people
The number who actually took part.
- Started
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Apr 2025
- Finished
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Oct 2025
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Generally healthy male and female participants who are between 18 - 65 years of age (inclusive). 2. Have a body mass index (BMI) range of 25.0 - 29.9 kg/m2 (inclusive). 3. Female participants must meet one of the following criteria: * Have a regular menstrual cycle, defined as a consistent cycle length of 24-32 days for participants in the main group and 26-32 days for participants in the subgroup and demonstrated during the screening period * No longer menstruate due to medication (e.g., those taking birth control shots like Depo-Provera®) * No longer menstruate due to being postmenopausal, surgical removal of ovaries, or medically documented ovarian failure 4. Have the habit of consuming food in the morning daily, and agree to fully consume a standardized high-carbohydrate breakfast within 15 minutes at Visit 2, Visit 3 and Visit 4. 5. Have veins suitable for repeated blood sampling in subgroup only. 6. Have maintained dietary habits and lifestyle within 3 months prior to screening and willing to maintain their habitual diets and lifestyle throughout the study. 7. Agree to follow the restrictions on concomitant treatments as listed 8. Willing and able to adhere to the requirements and restrictions of this study, willing to give voluntary consent, be able to understand and read the questionnaires, and carry out all study-related procedures. Exclusion Criteria: 1. Individuals who are lactating, pregnant or planning to become pregnant during the study. 2. Have a known sensitivity, intolerability, or allergy to any of the study products or their excipients. 3. Have Type I diabetes or Type II diabetes, high blood pressure (≥140 systolic or ≥90 diastolic mmHg), or uncontrolled thyroid disease ("uncontrolled" defined as being unmedicated, have an unstable use of medication within 3 months prior to screening, or have a stable use of medication for 3 months but still have uncontrolled conditions). 4. Current high fiber intake (estimated to be ≥ 30 g per day as estimated by a questionnaire at screening). 5. Currently participating in a weight management program or on a specific diet (e.g., Atkins, keto, intermittent fasting, etc.), or participated in a weight management program with its completion occurred within 3 months prior to baseline. 6. Experienced a change in body weight of ±4.5 kg (10 lbs.) over the 3 months prior to baseline. 7. Have eating disorder(s) (e.g., bulimia, binge eating disorder, etc.). 8. Have medical condition(s) known to manifest gastrointestinal symptoms (e.g., irritable bowel syndrome, endometriosis, etc.). 9. Have medical condition(s) known to interfere with absorption, distribution, metabolism, or excretion of the study product (e.g., Crohn's disease, short bowel, acute or chronic pancreatitis, or pancreatic insufficiency). 10. Have a history of heart/cardiovascular disease, renal disease (dialysis or renal failure), hepatic impairment/disease, immune disorders and/or immunocompromised (i.e., HIV/AIDS). 11. Have a history of cancer (except localized skin cancer without metastases or in situ cervical cancer) with recovery occurred within 5 years before the screening visit. 12. Are receiving treatments for or have been hospitalized in the last 12 months for psychiatric disorders (e.g., depression, bipolar disorder, schizophrenia, etc.). 13. Reports a clinically significant illness during the 28 days before the first dose of study product. 14. Major surgery in 3 months prior to screening or planned major surgery during the study. 15. Have a history of alcohol or substance abuse in the 12 months prior to screening (including having been hospitalized for such in an in-patient or out-patient intervention program) or use that to the opinion of the investigator may be of a concern for the study. 16. Currently, or plan to, live in the same household with another participant in the current study during the study period. 17. Current enrolment or past participation in another study with any product(s) with at least one active ingredient within 28 days before first dose of study product or longer, if the previous test product is deemed by the investigator to have lasting effects that might influence the eligibility criteria or outcomes of current study. 18. Any other medical condition/situation or use of medications/supplements/therapies that, in the opinion of the investigator, may adversely affect the participant's ability to participate in the study or its measures or pose a significant risk to the participant.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Boston Clinical Trials - Alcanza
Boston, Massachusetts, 02131, United States
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Indago Research Health Center,Inc.
Hileah, Florida, 33012, United States
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Vantage Clinical Trials, LLC
Tampa, Florida, 33614, United States
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