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Real-World dupixent study tracks Long-Term relief for sinusitis and nasal polyps

NCT ID NCT04959448

Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This study follows adults with chronic sinusitis and nasal polyps who are starting treatment with Dupixent (dupilumab). Researchers will track symptoms, quality of life, and safety over time in a real-world setting. The goal is to understand how well the medication works long-term and how it is used in everyday medical practice.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dupilumab (Dupixent)
What this could lead to
If successful, this study could confirm that long-term Dupixent use effectively controls symptoms and improves quality of life for people with chronic sinusitis and nasal polyps.
What could go wrong
This is an observational study, not a controlled trial, so results may be influenced by other factors. Long-term safety data are still being collected, and not all patients may respond equally.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

717 people

The number who actually took part.

Started

Aug 2021

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients who are initiating treatment with DUPIXENT® for CRSwNP according to the country-specific prescribing information.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Key Inclusion Criteria: * All patients who are newly initiated on DUPIXENT® for the treatment of CRSwNP according to the respective prescribing information (Product Label or SmPC) * Willing and able to comply with clinic visits and study-related procedures as per protocol * Provide informed consent signed by study patient or legally acceptable representative * Able to understand and complete study-related questionnaires as per protocol Key Exclusion Criteria: * Patients who have a contraindication to DUPIXENT® according to the country-specific prescribing information * Any previous treatment with DUPIXENT® for any condition * Any condition that, in the opinion of the investigator, may interfere with the patient's ability to participate in the study per protocol * Participation in an ongoing interventional or observational study that might, in the treating physician's opinion, influence the assessments for the current study per protocol

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic rhinosinusitis with nasal polyposis

Contacts and locations

Locations

  • AADRS Clincial Research Center

    Coral Gables, Florida, 33134, United States

  • ADAC research, PA

    Greenville, South Carolina, 29607, United States

  • AOU di Padova

    Padova, Veneto, 35128, Italy

  • ARK Clinical Research

    Long Beach, California, 90806, United States

  • Allergy & Asthma Center of Minnesota - Allergology

    Maplewood, Minnesota, 55109, United States

  • Allergy & Asthma Clinical Research

    Walnut Creek, California, 94598, United States

  • Allergy Partners of the Triangle

    Raleigh, North Carolina, 27607, United States

  • Allergy and Asthma Physicians of RI

    Lincoln, Rhode Island, 02865, United States

  • Alrijne Ziekenhuis

    Leiderdorp, South Holland, 2353, Netherlands

  • Amsterdam UMC location AMC

    Amsterdam, North Holland, 1105, Netherlands

  • Asthma & Allergy Center of Chicago

    Oak Park, Illinois, 60301, United States

  • Asthma, Nasal Disease & Allergy Research Center of New England

    East Providence, Rhode Island, 02914, United States

  • Atlantic Research Center LLC

    Ocean City, New Jersey, 07712, United States

  • Azienda Ospedaliero Universitara Policlinico di Catania

    Catania, Sicily, 95125, Italy

  • Azienda Ospedaliero Universitaria Senese

    Siena, Tuscany, 53100, Italy

  • Azienda Ospedaliero Universitaria di Sassari

    Sassari, 07100, Italy

  • Azienda Policlinico Umberto I - Università degli Studi di Roma "La Sapienza"

    Rome, 00161, Italy

  • Breathe Clear Institute

    Torrance, California, 90503, United States

  • Brigham & Women's Hospital

    Boston, Massachusetts, 02115, United States

  • Centre hospitalier de l'Université de Montréal

    Montreal, Quebec, H2X 3E4, Canada

  • Charité

    Berlin, Brandenburg, 10117, Germany

  • Damask Physicians Group

    Lake Mary, Florida, 32746, United States

  • Dr. Richard Gall Med Corp

    Winnipeg, Manitoba, R3P1C7, Canada

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • ENT & Allergy Partners

    Summerville, South Carolina, 29486, United States

  • ENT Clinic San Martino Hospital

    Genova, 16126, Italy

  • ENT Clinic Sinus Center, St. Paul's Hospital

    Vancouver, British Columbia, V6Z 1Y6, Canada

  • Eastern Virginia Medical School

    Norfolk, Virginia, 23510, United States

  • Emory University Hospital Midtown

    Atlanta, Georgia, 30308, United States

  • Essential Medical Research

    Tulsa, Oklahoma, 74137, United States

  • Excel ENT of Alabama

    Birmingham, Alabama, 35244, United States

  • Fondazione universitaria Policlinico A. Gemelli

    Rome, 00168, Italy

  • Fujisawa City Hospital

    Fujisawa, Kanagawa, 251-8550, Japan

  • Hopital Du Saint-Sacrement

    Québec, G1S 4L8, Canada

  • IACT Health

    Columbus, Georgia, 31904, United States

  • Indiana University Health

    Indianapolis, Indiana, 46202, United States

  • Istituto Clinico Humanitas

    Rozzano, Milano, 20089, Italy

  • John Hopkins University School Of Medicine

    Baltimore, Maryland, 21224, United States

  • Kyoto Nose & Allergy Clinic

    Kyoto, 600-8216, Japan

  • Matsuwaki Clinic Shinagawa

    Shinagawa-Ku, Tokyo, 141-0001, Japan

  • Medical Research of Arizona, a division of Allergy, Asthma & Immunology Associates

    Scottsdale, Arizona, 85251, United States

  • Medical University Of South Carolina

    Charleston, South Carolina, 29425, United States

  • Montefiore Medical Center

    New York, New York, 10461, United States

  • Nagaoka Red Cross Hospital - Otorhinolaryngology

    Nagaoka, Niigita, 940-2085, Japan

  • Northwell Health

    Great Neck, New York, 11021, United States

  • Northwestern University Feinberg School of Medicine

    Chicago, Illinois, 60611, United States

  • Oberhavelkliniken Hennigsdorf

    Hennigsdorf, Brandenburg, 16761, Germany

  • Onze Lieve Vrouwe Gasthuis

    Amsterdam, North Holland, 1091 AC, Netherlands

  • Osaka Haibikino Medical Center

    Habikino, Osaka, 583-8588, Japan

  • Praxis Dr. Yury Yarin

    Dresden, Saxony, 01139, Germany

  • Richmond Ear Nose & Throat

    Richmond, Virginia, 23235, United States

  • Rochester Regional Health System

    Rochester, New York, 14626, United States

  • STAAMP Research

    San Antonio, Texas, 78229, United States

  • Scripps Health - Scripps Clinic Carmel Valley

    San Diego, California, 92130, United States

  • Spartanburg Ear, Nose & Throat Clinical

    Spartanburg, South Carolina, 29303, United States

  • Tanner Clinic

    Layton, Utah, 84041, United States

  • The Allergy and Rheumatology Medical Clinic

    La Jolla, California, 92037, United States

  • The University of Chicago Medical Center UCMC Duchossois Center for Advanced Medicine DCAM

    Chicago, Illinois, 60637, United States

  • The Vancouver Clinic

    Vancouver, Washington, 98664, United States

  • Tokyo Kyosai Hospital

    Meguro-Ku, Tokyo, 153-8934, Japan

  • Toronto Allergy & Asthma Clinic-Pulmonology

    Toronto, Ontario, M5G 1E2, Canada

  • Treasure Valley Medical Research

    Boise, Idaho, 83706, United States

  • Universita Degli Studi di Pisa Ospedale di Cisanello Pisa

    Pisa, Tuscany, 56100, Italy

  • University Hospital Mannheim - Dermatology, Venerology, Allergology

    Mannheim, Baden-Wurttemberg, 68167, Germany

  • University Hospital Münster

    Münster, North Rhine-Westphalia, 48149, Germany

  • University of Cincinnati College of Medicine

    Cincinnati, Ohio, 45229, United States

  • University of Florida

    Gainesville, Florida, 32610, United States

  • University of Fukui Hospital - Otorhinolaryngology

    Yoshida-gun, Hukui, 910-1193, Japan

  • University of Illinois

    Chicago, Illinois, 60612, United States

  • University of Michigan, Michigan Medicine Pulmonary Clinic

    Ann Arbor, Michigan, 48109-5000, United States

  • University of Missouri

    Columbia, Missouri, 65212, United States

  • University of Nebraska Medical Center

    Omaha, Nebraska, 68198, United States

  • University of Rochester Medical Center

    Rochester, New York, 14642, United States

  • University of South Florida

    Tampa, Florida, 33612, United States

  • University of Virginia Health System (UVA)

    Charlottesville, Virginia, 22903, United States

  • Università Degli Studi Magna Graecia di Catanzaro

    Catanzaro, 88100, Italy

  • Universitätsklinikum Düsseldorf

    Düsseldorf, North Rhine-Westphalia, 40225, Germany

  • Universitätsklinikum Jena

    Jena, Thuringia, 07740, Germany

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

  • Wake Forest Baptist Health

    Winston-Salem, North Carolina, 27157, United States

  • Zentrum für Rhinologie

    Wiesbaden, Hesse, 65183, Germany

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