Real-World dupixent study tracks Long-Term relief for sinusitis and nasal polyps

NCT ID NCT04959448

Ongoing Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This study follows adults with chronic sinusitis and nasal polyps who are starting treatment with Dupixent (dupilumab). Researchers will track symptoms, quality of life, and safety over time in a real-world setting. The goal is to understand how well the medication works long-term and how it is used in everyday medical practice.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: dupilumab (Dupixent)
What this could lead to: If successful, this study could confirm that long-term Dupixent use effectively controls symptoms and improves quality of life for people with chronic sinusitis and nasal polyps.
What could go wrong: This is an observational study, not a controlled trial, so results may be influenced by other factors. Long-term safety data are still being collected, and not all patients may respond equally.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC RHINOSINUSITIS WITH NASAL POLYPOSIS

Contacts and locations

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Locations

AADRS Clincial Research Center

Coral Gables, Florida, 33134, United States
ADAC research, PA

Greenville, South Carolina, 29607, United States
AOU di Padova

Padova, Veneto, 35128, Italy
ARK Clinical Research

Long Beach, California, 90806, United States
Allergy & Asthma Center of Minnesota - Allergology

Maplewood, Minnesota, 55109, United States
Allergy & Asthma Clinical Research

Walnut Creek, California, 94598, United States
Allergy Partners of the Triangle

Raleigh, North Carolina, 27607, United States
Allergy and Asthma Physicians of RI

Lincoln, Rhode Island, 02865, United States
Alrijne Ziekenhuis

Leiderdorp, South Holland, 2353, Netherlands
Amsterdam UMC location AMC

Amsterdam, North Holland, 1105, Netherlands
Asthma & Allergy Center of Chicago

Oak Park, Illinois, 60301, United States
Asthma, Nasal Disease & Allergy Research Center of New England

East Providence, Rhode Island, 02914, United States
Atlantic Research Center LLC

Ocean City, New Jersey, 07712, United States
Azienda Ospedaliero Universitara Policlinico di Catania

Catania, Sicily, 95125, Italy
Azienda Ospedaliero Universitaria Senese

Siena, Tuscany, 53100, Italy
Azienda Ospedaliero Universitaria di Sassari

Sassari, 07100, Italy
Azienda Policlinico Umberto I - Università degli Studi di Roma "La Sapienza"

Rome, 00161, Italy
Breathe Clear Institute

Torrance, California, 90503, United States
Brigham & Women's Hospital

Boston, Massachusetts, 02115, United States
Centre hospitalier de l'Université de Montréal

Montreal, Quebec, H2X 3E4, Canada
Charité

Berlin, Brandenburg, 10117, Germany
Damask Physicians Group

Lake Mary, Florida, 32746, United States
Dr. Richard Gall Med Corp

Winnipeg, Manitoba, R3P1C7, Canada
Duke University Medical Center

Durham, North Carolina, 27710, United States
ENT & Allergy Partners

Summerville, South Carolina, 29486, United States
ENT Clinic San Martino Hospital

Genova, 16126, Italy
ENT Clinic Sinus Center, St. Paul's Hospital

Vancouver, British Columbia, V6Z 1Y6, Canada
Eastern Virginia Medical School

Norfolk, Virginia, 23510, United States
Emory University Hospital Midtown

Atlanta, Georgia, 30308, United States
Essential Medical Research

Tulsa, Oklahoma, 74137, United States
Excel ENT of Alabama

Birmingham, Alabama, 35244, United States
Fondazione universitaria Policlinico A. Gemelli

Rome, 00168, Italy
Fujisawa City Hospital

Fujisawa, Kanagawa, 251-8550, Japan
Hopital Du Saint-Sacrement

Québec, G1S 4L8, Canada
IACT Health

Columbus, Georgia, 31904, United States
Indiana University Health

Indianapolis, Indiana, 46202, United States
Istituto Clinico Humanitas

Rozzano, Milano, 20089, Italy
John Hopkins University School Of Medicine

Baltimore, Maryland, 21224, United States
Kyoto Nose & Allergy Clinic

Kyoto, 600-8216, Japan
Matsuwaki Clinic Shinagawa

Shinagawa-Ku, Tokyo, 141-0001, Japan
Medical Research of Arizona, a division of Allergy, Asthma & Immunology Associates

Scottsdale, Arizona, 85251, United States
Medical University Of South Carolina

Charleston, South Carolina, 29425, United States
Montefiore Medical Center

New York, New York, 10461, United States
Nagaoka Red Cross Hospital - Otorhinolaryngology

Nagaoka, Niigita, 940-2085, Japan
Northwell Health

Great Neck, New York, 11021, United States
Northwestern University Feinberg School of Medicine

Chicago, Illinois, 60611, United States
Oberhavelkliniken Hennigsdorf

Hennigsdorf, Brandenburg, 16761, Germany
Onze Lieve Vrouwe Gasthuis

Amsterdam, North Holland, 1091 AC, Netherlands
Osaka Haibikino Medical Center

Habikino, Osaka, 583-8588, Japan
Praxis Dr. Yury Yarin

Dresden, Saxony, 01139, Germany
Richmond Ear Nose & Throat

Richmond, Virginia, 23235, United States
Rochester Regional Health System

Rochester, New York, 14626, United States
STAAMP Research

San Antonio, Texas, 78229, United States
Scripps Health - Scripps Clinic Carmel Valley

San Diego, California, 92130, United States
Spartanburg Ear, Nose & Throat Clinical

Spartanburg, South Carolina, 29303, United States
Tanner Clinic

Layton, Utah, 84041, United States
The Allergy and Rheumatology Medical Clinic

La Jolla, California, 92037, United States
The University of Chicago Medical Center UCMC Duchossois Center for Advanced Medicine DCAM

Chicago, Illinois, 60637, United States
The Vancouver Clinic

Vancouver, Washington, 98664, United States
Tokyo Kyosai Hospital

Meguro-Ku, Tokyo, 153-8934, Japan
Toronto Allergy & Asthma Clinic-Pulmonology

Toronto, Ontario, M5G 1E2, Canada
Treasure Valley Medical Research

Boise, Idaho, 83706, United States
Universita Degli Studi di Pisa Ospedale di Cisanello Pisa

Pisa, Tuscany, 56100, Italy
University Hospital Mannheim - Dermatology, Venerology, Allergology

Mannheim, Baden-Wurttemberg, 68167, Germany
University Hospital Münster

Münster, North Rhine-Westphalia, 48149, Germany
University of Cincinnati College of Medicine

Cincinnati, Ohio, 45229, United States
University of Florida

Gainesville, Florida, 32610, United States
University of Fukui Hospital - Otorhinolaryngology

Yoshida-gun, Hukui, 910-1193, Japan
University of Illinois

Chicago, Illinois, 60612, United States
University of Michigan, Michigan Medicine Pulmonary Clinic

Ann Arbor, Michigan, 48109-5000, United States
University of Missouri

Columbia, Missouri, 65212, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States
University of Rochester Medical Center

Rochester, New York, 14642, United States
University of South Florida

Tampa, Florida, 33612, United States
University of Virginia Health System (UVA)

Charlottesville, Virginia, 22903, United States
Università Degli Studi Magna Graecia di Catanzaro

Catanzaro, 88100, Italy
Universitätsklinikum Düsseldorf

Düsseldorf, North Rhine-Westphalia, 40225, Germany
Universitätsklinikum Jena

Jena, Thuringia, 07740, Germany
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Wake Forest Baptist Health

Winston-Salem, North Carolina, 27157, United States
Zentrum für Rhinologie

Wiesbaden, Hesse, 65183, Germany

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