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New clamp technique may improve survival in aortic tear surgery

NCT ID NCT07150559

Disease control Sponsor: Beijing Anzhen Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new surgical method called arch-clamping under mild hypothermia for people with a life-threatening tear in the aorta (acute type A aortic dissection). The trial will enroll 306 adults across 7 hospitals in China, comparing the new technique to standard approaches. The goal is to see if it reduces major complications like death, stroke, kidney failure, and paralysis, while also shortening time on a heart-lung machine and in the ICU.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Arch-clamping surgical procedure under mild hypothermia
What this could lead to
If successful, this technique could reduce serious complications and recovery time for people undergoing emergency aortic dissection repair.
What could go wrong
This is an early-stage surgical technique trial with 306 participants, so results may not apply to all patients. The procedure carries inherent risks like stroke, kidney failure, or death.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 306 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Feb 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Aortic CTA confirmed as ATAAD according to the 2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease; 2. Adult patients (18-70 years) weighing 50-120 kg; 3. Time interval between the onset of symptoms and operation is less than 14 days; 4. Indications for total aortic arch replacement are available; 5. Signed informed consent and availability for follow-up. Exclusion Criteria: 1. History of chronic renal failure, hepatocirrhosis, and hepatic insufficiency; 2. Severe gastrointestinal complications of non-aortic dissection, such as mesenteric ischemia, gastrointestinal bleeding, hepatopancreaticobiliary dysfunction, and intestinal obstruction; 3. History of severe cerebral infarction (with cerebral infarction sequels); 4. Preoperative intubation or unconsciousness; 5. Inflammatory aortic diseases, such as Takayasu arteritis and Behçet's disease, etc; 6. History of infectious aortic diseases; 7. History of cardiac and aortic surgery; 8. History of malignancy or previous radiotherapy; 9. Pregnant or feeding women, or anyone planning to reproduce during the test period; 10. Without an informed consent signature; 11. Participating in any other clinical trial; 12. Having other causes not eligible for operation.

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Conditions

The condition(s) this trial relates to.

Hypothermia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute type A aortic dissection Bilateral antegrade cerebral perfusion Frozen elephant trunk Hypothermia Total aortic arch replacement

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Beijing Anzhen Hospital

    RECRUITING

    Beijing, Beijing Municipality, 100013, China

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