Could your own blood heal a numb cornea? new trial tests Platelet-Rich eye drops
NCT ID NCT04604834
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether eye drops made from a patient's own blood (called autologous platelet-rich plasma, or APRP) can heal the cornea better than standard artificial tears in people with neurotrophic keratopathy, a condition where the cornea loses feeling and cannot heal properly. About 39 adults with corneal damage will try each treatment for four weeks in a crossover design. Researchers will measure changes in corneal staining, sensitivity, tear quality, symptoms, and vision over 12 weeks.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- autologous platelet-rich plasma (APRP) eye drops
- What this could lead to
- If it works, this could offer a more effective treatment for neurotrophic keratopathy, a chronic eye condition that is hard to manage with standard artificial tears.
- What could go wrong
- This is a small, early-phase crossover trial with only 39 participants, so results may not apply to everyone. The treatment is made from each patient's own blood, so quality can vary, and it may not work better than existing options.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 39 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Nov 2020
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients with: * Neurotrophic keratopathy diagnosed by esthesiometry (defined as central corneal sensitivity ≤ 3cm using Cochet-Bonnet aesthesiometer). * Corneal erosions. * Neurotrophic keratopathy secondary to: diabetes mellitus, herpetic keratitis, microbial keratitis sequelae (bacteria, Acanthamoeba, fungi, herpes), limbal stem cell deficiency, chemical or thermic burn sequelae at least 3 months after the accident, ocular trauma with penetrating wound fixed at least 3 months before the trial, surgery carried out at least 3 month before the trial (including keratoplasty, laser in situ keratomileusis, phacoemulsification cataract surgery, extracapsular cataract extraction), adenoviral keratoconjunctivitis resolved at least 3 months the trial. Exclusion Criteria: * Patients diagnosed with: * Other ocular surface pathology presenting with corneal erosions but without corneal hyposensitivity. * Corneal epithelial defect with or without corneal hyposensitivity. * Pregnant women, homeless, migrants.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Departamento de Oftalmologia, Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
RECRUITINGMonterrey, Nuevo León, 64460, Mexico
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