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Aging proteins in artery walls could be key to aneurysm mystery

NCT ID NCT02784769

Knowledge-focused Sponsor: CHU de Reims Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether natural aging of proteins in blood vessel walls contributes to the development of aortic aneurysms. Researchers measured skin autofluorescence and collected blood and skin samples from 24 patients undergoing surgery for abdominal aortic aneurysms. The goal was to better understand the role of protein aging in aneurysm formation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help explain why aortic aneurysms develop, potentially pointing toward future prevention or treatment strategies.
What could go wrong
This is a small, observational study with only 24 participants. It aims to understand the disease, not test a treatment, so direct patient benefits are unlikely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

24 people

The number who actually took part.

Start date

Feb 2015

Finished

Nov 2016

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with aneurysm of the infrarenal abdominal aorta requiring surgical care by open surgery. * Patients older than 18 years. * Patients who agreed to participate in the study. Exclusion Criteria: * Patients with aneurysm of the abdominal infrarenal aorta due to trauma or infection. * Patients who have already received surgery for an aneurysm of abdominal aorta. * Patients who are protected by law.

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Conditions

The condition(s) this trial relates to.

abdominal aortic aneurysm aortic aneurysm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aortic aneurysm

Contacts and locations

Locations

  • Chu Reims

    Reims, 51092, France

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Other studies related to the condition(s) this trial covers.