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No drill, no fear? new gel could change how we treat cavities

NCT ID NCT07344415

Symptom relief Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new gel that dissolves tooth decay without drilling, aiming to reduce patient anxiety. Eighty adults with cavities in lower molars will be randomly assigned to either the gel or a standard drill. The main goal is to see which method causes less pain and discomfort during treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Cariemove gel (contains sodium hypochlorite and amino acids)
What this could lead to
If it works, this gel could make cavity treatment less scary and painful, reducing the need for drills and needles.
What could go wrong
This is a small, early-stage trial with only 80 participants, so results may not apply to everyone. The gel may not remove all decay or could be slower than drilling.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2025

An estimate. Start dates often move.

Expected to finish

Jan 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

10 to 25 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Open carious lesions with dentin involvement, but not involving the pulp in lower molars. 2. The access of the carious lesion has to be large enough to allow the penetration of the excavator. 3. Asymptomatic vital teeth, without clinical evidence of pulp, furcation, or periapical pathology. 4. Patients who sign informed consent. 5. Co-operative patients approving to participate in the trial. Exclusion Criteria: 1. Patients with spontaneous or elicited pain from caries. 2. Patients with systemic diseases. 3. Presence of intraoral/extraoral swellings. 4. Deep dental caries involving pulp. 5. Presence of swelling/fistula in relation to carious tooth. 6. Inability to return for recall visits. 7. Patients with bad oral hygiene 8. Refuse to participate in the study.

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Conditions

The condition(s) this trial relates to.

anxiety disorder dental caries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Caries active

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Faculty of Dentistry Cairo University

    Cairo, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.