Sweetener showdown: can monk fruit or splenda help stop cavities?
NCT ID NCT06921434
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests how mouth rinses made with monk fruit or Splenda affect saliva acidity and levels of cavity-causing bacteria. 90 healthy young adults (ages 20-24) with no active cavities will rinse with one of the sweetener solutions. Saliva samples will be checked before rinsing and up to 30 minutes after to see which sweetener better controls cavity risk.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 90 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2025
An estimate. Start dates often move.
- Expected to finish
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Dec 2025
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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20 to 24 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: participants aged (20-24) years. * No active carious lesions or oral diseases. * Generally healthy individuals without systemic illnesses. * No prior use of preventive dental treatments Exclusion Criteria: * Participants currently undergoing dental treatment. * Those taking medications that alter saliva flow. * Presence of painful oral conditions or systemic diseases. Participants have active caries
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
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Contacts and locations
Locations
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Almustansiriyah university
Baghdad, Iraq, Iraq
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Other studies related to the condition(s) this trial covers.