New hope for heart surgery patients whose blood thinners fail

NCT ID NCT06096116

Recruiting now Disease control Sponsor: Octapharma Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 21, 2026 · Updated 28 times

Summary

This study tests a medicine called Atenativ in 120 adults having heart surgery who do not respond well to the standard blood thinner heparin. The goal is to see if Atenativ can restore heparin's effectiveness during surgery, reducing the need for extra treatments. Participants will receive either Atenativ or a placebo, and researchers will monitor how well their blood thins during the procedure.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Atrium Health Wake Forest Baptist
RECRUITING

Winston-Salem, North Carolina, 27157, United States
CHU de Reims, Hôpital Robert Debré
TERMINATED

Reims, France
CHU de Rennes
WITHDRAWN

Rennes, France
Center of Cardiovascular and Transplant Surgery
RECRUITING

Brno, Czechia
Cleveland Clinic
NOT_YET_RECRUITING

Cleveland, Ohio, 44195, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710-1000, United States
Hospital of Lithuanian university of Health sciences Kauno Klinikos
RECRUITING

Kaunas, Lithuania
Institute for Cardiovascular Diseases C.C. Iliescu
RECRUITING

Bucharest, Romania
Institute for Clinical and Experimental Medicine
RECRUITING

Prague, Czechia
Institute of Cardiovascular Diseases Vojvodina
NOT_YET_RECRUITING

Kamenitz, Serbia
Kingston Health Sciences Centre
RECRUITING

Kingston, Ontario, K7L2V7, Canada
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Montreal Heart Institute
RECRUITING

Montreal, Quebec, H1T1C8, Canada
OU Health University of Oklahoma Medical Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
Royal Columbian Hospital
RECRUITING

New Westminster, British Columbia, V3L0A4, Canada
Royal Papworth Hospital
RECRUITING

Cambridge, United Kingdom
Stanford University School of Medicine
RECRUITING

Stanford, California, 94305-5101, United States
The James Cook University Hospital
RECRUITING

Middlesbrough, United Kingdom
The Ohio State University
RECRUITING

Columbus, Ohio, 43214, United States
Toronto General Hospital
RECRUITING

Toronto, Ontario, M5G2C4, Canada
University Hospital Coventry and Warwickshire
RECRUITING

Coventry, United Kingdom
University Hospital Innsbruck
RECRUITING

Innsbruck, Austria
University Medical Centre Ljubljana
RECRUITING

Ljubljana, Slovenia
University of Miami
RECRUITING

Miami, Florida, 33136, United States
University of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
Vienna General Hospital AKH, Medical University of Vienna
RECRUITING

Vienna, Austria
Vilnius University hospital Santaros Klinikos
RECRUITING

Vilnius, Lithuania

Conditions

Explore the condition pages connected to this study.

ACQUIRED ANTITHROMBIN DEFICIENCY