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Antibiotics for UTIs may disrupt gut bacteria, study finds

NCT ID NCT07424989

Knowledge-focused Sponsor: University Hospital, Rouen Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how antibiotics used to treat urinary tract infections (UTIs) affect the bacteria in the gut. Researchers collected stool samples from 61 hospitalized patients before and after antibiotic treatment to see if resistant bacteria increased. The goal was to understand potential side effects of antibiotics on digestive health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
antibiotics (ceftriaxone, piperacillin/tazobactam, or temocillin)
What this could lead to
If successful, this could help doctors understand how antibiotic treatments for UTIs affect gut bacteria and the spread of antibiotic resistance.
What could go wrong
This is a small, completed observational study that does not test a new treatment. It only measures changes in gut bacteria, so it may not lead to direct clinical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

61 people

The number who actually took part.

Started

Jul 2021

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients will be recruited via the Emergency Department (ED).

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patient requiring hospitalisation * Diagnosis of urinary tract infection requiring systemic antibiotic therapy with ceftriaxone, piperacillin/tazobactam or temocillin * Collection of a stool sample possible before or within 24 hours of starting systemic antibiotic therapy * Patient who has read and understood the information letter and given their consent to participate in the research Exclusion Criteria: * Minor patient * Patient hospitalised in an intensive care unit * Digestive stoma * Patient not affiliated with social security * Pregnant woman, woman in labour or breastfeeding woman * Person deprived of liberty by administrative or judicial decision * Person placed under judicial protection, guardianship or curatorship

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Conditions

The condition(s) this trial relates to.

urinary tract infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Urinary tract infection(UTI)

Contacts and locations

Locations

  • CHU de Rouen

    Rouen, 76031, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.