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Common surgery antibiotics may trigger confusion in seniors

NCT ID NCT07673510

Knowledge-focused Sponsor: Chinese PLA General Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time

Summary

This study looks at whether certain antibiotics given before surgery are linked to postoperative delirium in adults over 65 having elective non-cardiac surgery. Researchers will track antibiotic use and check for delirium twice daily. The goal is to provide safety evidence to guide antibiotic choices and help prevent confusion after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
perioperative antibiotics (beta-lactams, nitroimidazoles, glycopeptides, fluoroquinolones, and others)
What this could lead to
If a link is found, surgeons may choose safer antibiotics to reduce delirium risk in older patients.
What could go wrong
This is an observational study, so it can show an association but not prove cause. Results may not apply to all surgery types or hospitals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

4,711 people

The number who actually took part.

Started

Apr 2020

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study included older adult patients (aged 65 years) scheduled for elective non-cardiac surgery in the First Medicine Department of the Chinese PLA General Hospital between April 2020 and April 2022, from whom complete medication records were obtained.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * patients over 65 years old * patients undergoing elective non-cardiac surgery Exclusion Criteria: * older adult patients who had history of psychotic disorders * history of neurological disease * conditions that would make assessments for delirium unreliable * preoperative infection * severe hepatic and renal dysfunction, minor and intermediate clean-incision surgery * missing data exceeding 5%, and no medication records

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Conditions

The condition(s) this trial relates to.

delirium Emergence Delirium

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Delirium, postoperative

Contacts and locations

Locations

  • Chinese PLA General Hospital, Beijing

    Beijing, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.