Antibiotics may temporarily alter gut nerve cells, new study finds
NCT ID NCT05834036
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at how a short course of antibiotics changes the nerve and glia cells in the lower gut of 10 healthy adults. Researchers took colon tissue samples before and after antibiotic treatment to count these cells and measure gene activity. The goal was to understand if antibiotics can temporarily affect the gut's nervous system, which may help explain digestive issues after antibiotic use.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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10 people
The number who actually took part.
- Started
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Jun 2023
- Finished
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Nov 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * 18-75 years old of different sex and races. Exclusion Criteria: * Allergy to penicillin, amoxicillin, augmentin, ampicillin, and other antibiotics in the penicillin family * Pregnancy or fertility treatments * Usage of antibiotics, antifungals or antivirals within three months prior to participation * Change in dietary habits within the last three months prior to participation such as transitioning from high fat western diet to primarily plant based diet, initiation of ketogenic, paleo or any other weight loss regimen. * Acute (in the past 30 days) or chronic enteric infections, including C. difficile. * Chronic gastrointestinal disorder including inflammatory bowel disease, celiac disease , irritable bowel syndrome, chronic constipation or diarrhea * Active neuropsychiatric disorder that requires anti-psychotic ie typical and atypical antipsychotics as well as anti-epileptics, levodopa, rivastigmine or any other neuropsychiatric medication with dopaminergic and cholinergic effects. * Myocardial infarction or cerebrovascular accident in the six months prior to participation * Coagulation disorders * Chronic immunosuppressive medication (systemic) usage * Anti-coagulation and anti-platelet agents such as plavix, warfarin, heparin, direct oral anticoagulants. * Low dose Aspirin does not constitute an exclusion criteria. * Prior episode of C. difficile infection. * Prosthetic heart valves or any other conditions that require pre-procedure antibiotics. * Currently receiving chemotherapy * Any medical, psychological or social condition, in the opinion of the investigator, would jeopardize the health or well-being of the participant, interfere with their participation in the study, or confound the results of the study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Rockefeller University
New York, New York, 10065, United States