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Brain training for wobbly ankles? new study hopes to personalize rehab

NCT ID NCT06576687

Knowledge-focused Sponsor: University of Nebraska Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study from the University of Nebraska aims to understand why some people with chronic ankle instability have different problems—some have loose ligaments, others have poor brain control. Researchers will test 42 physically active adults, including healthy controls, people coping with ankle issues, and those with chronic instability. Participants will do balance and hop exercises while brain activity and movement are measured. The goal is to find better ways to tailor rehabilitation to each person's specific needs.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Balance and hop-training exercises
What this could lead to
If successful, this could lead to more personalized rehabilitation programs for people with chronic ankle instability, improving recovery and reducing recurrence.
What could go wrong
This is a small, early-stage observational and interventional study (42 participants) focused on understanding mechanisms, not proving a treatment works. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 42 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2025

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 to 45 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * All participants must be physically active (participation in at least 90 total minutes of activity/week including running, walking, lifting weights, or playing a sport, etc.) * Healthy controls: * no history of lateral ankle sprain * no complaints of their ankle giving way * a Cumberland Ankle Instability Tool (CAIT) score greater than 28 * Coper participants (participants coping with ankle problems: * a history of lateral ankle sprain, but no episodes of giving way in previous 12 months * CAIT score greater than 28 * Chronic ankle instability (CAI): * history of ankle sprain * two or more episodes of ankle giving way in previous 12 months * CAIT score less than 25 Exclusion Criteria: * History of lower extremity surgery or fracture * Current signs or symptoms of a joint sprain in the lower extremity * Pregnancy * Diagnosis of a vestibular disorder * Diagnosis of a nerve or connective tissue disorder * Significant history of condition that impaired cognitive function such as concussion or learning disability * Currently taking medications that may affect cognitive function such as narcotics, anti-depressants, anti-anxiety agents, or stimulants

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Conditions

The condition(s) this trial relates to.

ankle injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ankle injuries

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Nebraska-Omaha, Biomechanics Research Building

    Omaha, Nebraska, 68182, United States

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