Could a common hormone beat dangerous Post-Surgery low blood pressure?
NCT ID NCT06487585
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether angiotensin II, a drug that narrows blood vessels, can safely and effectively treat dangerously low blood pressure after heart surgery. About 100 adults undergoing heart surgery with a heart-lung machine will receive the drug as a first-line treatment. Researchers will track complications like kidney injury and irregular heartbeat over 28 days.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Angiotensin II
- What this could lead to
- If successful, this could provide a new, more effective first-line option to stabilize blood pressure after heart surgery, potentially reducing serious complications like kidney injury and irregular heartbeat.
- What could go wrong
- This is a small, early-phase 4 trial with only 100 participants, so results may not apply to all patients. The drug may not outperform existing treatments and could have side effects like excessive blood pressure elevation.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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About 100 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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May 2025
- Expected to finish
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Feb 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult patients ≥ 18 years of age undergoing cardiac surgery requiring CPB * Patients must have clinical features of vasodilation as determined by a MAP \< 65 mmHg that is non-transient in the opinion of the treating physician * Patients must be adequately volume resuscitated in the opinion of the treating physician * Systemic Vascular Resistance index (SVRi) \< 1970 dynes·sec/cm⁵/m² to support the clinical diagnosis of vasodilation; if no pulmonary artery catheter is in place, vasodilatory hypotension diagnosis according to the judgement of the critical care team * Biventricular systolic function is at or greater than pre-cardiopulmonary bypass baseline as demonstrated by echocardiographic evaluation, or the patient is concomitantly treated with Exclusion Criteria: * Bleeding as primary etiology of hypotension, as determined by \> 4 units RBC transfusion in 24 hours. * Patients on ECMO * Patients with active endocarditis * Patients already on renal replacement therapy or creatinine of \> 4 mg/dl within 2 weeks of surgery * Patients with contraindications to Angiotensin II including women who are pregnant or breastfeeding or have active coronary ischemia, mesenteric ischemia, limb ischemia, or high potassium (\> 5.5 meq/L) while receiving Angiotensin II
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University of Maryland St. Joseph Medical Center
RECRUITINGTowson, Maryland, 21204, United States