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The right mix: can anesthetic make knee arthritis shots work better?

NCT ID NCT05906433

NEW Symptom relief Sponsor: Foundation for Orthopaedic Research and Education Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 23, 2026 · Last updated Sep 23, 2026

Summary

Researchers are testing whether adding a numbing anesthetic to corticosteroid knee injections improves pain relief for people with knee osteoarthritis. The trial compares injections with and without anesthetic, and also tests different amounts of anesthetic. About 75 adults with mild to moderate knee arthritis will receive a single injection and report their pain levels over time. The goal is to learn which mixture eases pain best and how long relief lasts.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Kenalog (a corticosteroid) mixed with bupivacaine, a numbing anesthetic
What this could lead to
If one mix works better, doctors could tailor knee arthritis injections to give faster and longer pain relief.
What could go wrong
This is a small early-phase study, so results may not hold for all patients. Injections can cause temporary soreness, and steroid shots carry small risks of joint irritation or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

75 people

The number who actually took part.

Started

Jun 2023

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients must be 18 years of age and be able to consent for themselves. 2. OA grade Kellgren Lawrence Stage II or III. 3. Diagnosis of primary osteoarthritis. Exclusion Criteria: 1. Patients with other forms of arthritis such as inflammatory arthritis. 2. History of narcotic use for the past 6 months. 3. Kellgren Lawrence arthritis grade 1 or 4. 4. Pregnant women and prisoners.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee osteoarthritis

Contacts and locations

Locations

  • Florida Orthopaedic Institute

    Tampa, Florida, 33637, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.