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Which anesthesia is safer for aging brains? new study investigates

NCT ID NCT06353516

Knowledge-focused Sponsor: Chung-Ang University Gwangmyeong Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how two different anesthesia methods—intravenous propofol versus inhaled sevoflurane gas—affect the brain's protective barrier and the risk of confusion after surgery in 154 older adults (age 60+). Researchers measured a protein in the blood that indicates brain barrier leakage and tracked whether patients developed delirium or cognitive problems. The goal is to find out if one type of anesthesia is better at protecting the brain during surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Propofol (intravenous) and sevoflurane (inhaled gas)
What this could lead to
If one anesthesia type is found to better protect the brain's barrier, it could help reduce confusion and memory problems after surgery in older adults.
What could go wrong
This is a small, completed study measuring blood markers, not a direct test of long-term outcomes. Results may not apply to all surgeries or patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

154 people

The number who actually took part.

Started

Apr 2024

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * age equal to or older than 60 * american Society of Anesthesiologists (ASA) grade I to III * general anesthesia longer than 2 hours Exclusion Criteria: * history of dementia * history of schizophrenia, epilepsy, or Parkinson's disease * history of stroke or craniectomy * patient denial

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Conditions

The condition(s) this trial relates to.

delirium Neuroinflammatory Diseases Postoperative Cognitive Complications

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative cognitive dysfunction

Contacts and locations

Locations

  • Chung-Ang University Gwangmyeong Hospital

    Gwangmyeong, Gyeonggi-do, 14353, South Korea

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