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Could the choice of anesthesia quiet the Body's surgical stress response?

NCT ID NCT07760402

Knowledge-focused Sponsor: University of Gaziantep Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This trial asks whether the type of anesthesia used during kidney donation surgery influences the body's inflammatory response at a genetic level. Healthy living kidney donors will be randomly assigned to receive either propofol (intravenous) or sevoflurane (inhaled) for general anesthesia. Researchers will measure levels of three specific microRNAs—molecules that help regulate inflammation—in blood samples taken before, right after, and 24 hours after surgery. The goal is to see if one anesthesia method is associated with a more controlled inflammatory response, which could inform safer anesthesia practices for donors and potentially improve kidney quality for transplant.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Two anesthesia drugs: propofol (given intravenously) and sevoflurane (inhaled as a gas)
What this could lead to
If successful, this could help identify which anesthesia method causes less inflammation during kidney donation surgery, potentially improving donor recovery and protecting the donated kidney.
What could go wrong
This is a small, early-stage study with only 34 participants, so results may not apply broadly. It measures molecular markers, not direct health outcomes, and the clinical significance of any differences is uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 34 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2026

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Living kidney donors aged between 18 and 65 years. * Scheduled for an elective donor nephrectomy operation under general anesthesia. * American Society of Anesthesiologists (ASA) physical status I or II. * Body Mass Index (BMI) strictly less than 35 kg/m². * Provided written informed voluntary consent to participate in the study. Exclusion Criteria: * Known history or clinical diagnosis of malignancy or Diabetes Mellitus (DM). * Active or history of chronic systemic inflammatory or autoimmune diseases. * Chronic use of analgesics or documented history of substance abuse. * Known hypersensitivity or allergic reaction to any of the anesthetic agents used in the study (Sevoflurane or Propofol). * Diagnosed with dementia, severe cognitive impairment, or any significant psychiatric disorder.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Kidney transplant

How to take part

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  2. The official record

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    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Gaziantep University Sahinbey Research and Application Hospital

    RECRUITING

    Gaziantep, Sahinbey, 27310, Turkey (Türkiye)

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