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Can a chromium blend help menopausal women maintain muscle?
NCT ID NCT07402382
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at whether an amylopectin chromium blend can improve how the body uses protein and controls blood sugar in women going through or past menopause. Sixty women aged 40-65 will take the supplement or a placebo after a short exercise session. The goal is to see if this simple supplement can support muscle health and metabolic function during midlife.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- amylopectin-chromium blend (dietary supplement)
- What this could lead to
- If it works, this could point toward a nutritional strategy to support muscle maintenance and metabolic health in midlife women.
- What could go wrong
- This is a small, early-stage study (60 participants) testing an acute effect, not a long-term treatment. Results may not translate to real-world benefits or generalise beyond this group.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Nov 2025
- Expected to finish
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Sep 2026
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 to 70 years
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria:• Women aged 40-65 years who meet either of the following menstrual-history criteria: * ≥ 60 days but \< 12 months of amenorrhea (late perimenopause) * Women with ≥ 12 months of spontaneous amenorrhea (post-menopausal) * No more than 3 days per week of structured physical activity * Provide voluntary signed and dated informed consent. * Be in good health and able to participate in an exercise bout as determined by assessment, medical history, and routine blood chemistries. * Between the of 40 and 65 years of age (inclusive). * Body Mass Index of 18.5-34.9 (inclusive). * Body weight of at least 110 pounds. * Normotensive (seated, resting systolic blood pressure \<140 mm Hg and diastolic blood pressure \< 90 mm Hg. If the first measurement is slightly elevated above these limits, the subject will be given a brief (5-minute) rest period, and two more measurements will be taken. The average of all three measurements will be used to determine eligibility. * Normal supine, resting heart rate (\<90 per minute). * Subject agrees to follow standardized controlled diet for 3 days and maintain existing dietary patterns on other days throughout the study period. * Subject is willing and able to comply with the study protocol. * Able to provide an adequate blood draw. * If a dietary supplement was initiated within the past month, the participant is willing to discontinue supplement use followed by a 2-week washout prior to participation in the study. Note: A generic multivitamin is allowed. * Refrain from caffeine, exercise, and alcohol for 24 hours prior, and fast for 10 hours prior to each visit. Exclusion Criteria: * Current use of any dietary ingredient that impacts glucose control or insulin sensitivity. * Current vegans or vegetarians. * Intolerance to dairy foods/drinks. * Smokes more than 10 cigarettes per day or uses other nicotine products (i.e. vape, patch) that deliver a similar amount of nicotine. * History of malignancy in the previous 5 years except for non-melanoma skin cancer (basal cell cancer or squamous cell cancer of the skin). * Prior gastrointestinal bypass surgery (Lapband, etc.). * Individuals using any kind of GLP-1 medications. * Other known gastrointestinal or metabolic diseases that might impact nutrient absorption or metabolism, e.g. electrolyte abnormalities, diabetes, thyroid disease, adrenal disease, hypogonadism, short bowel syndrome, diarrheal illnesses, history of colon resection, gastric ulcer, reflux disease, gastroparesis, Inborn-Errors-of-Metabolism (such as PKU). * Individuals who have gained or lost more than 10 pounds within the last 30 days. * Individuals who are cognitively impaired and/or who are unable to give informed consent. * Chronic medically diagnosed inflammatory condition or disease (e.g. rheumatoid arthritis, Crohn's disease, ulcerative colitis, Lupus, HIV/AIDS, etc.). * Medical history of hepatorenal, musculoskeletal, autoimmune, or neurologic disease. * Known sensitivity to any ingredient in the test formulations as listed in the Certificates-of-Analysis. * Any other diseases or conditions that, in the opinion of the medical staff, could confound the primary endpoint or place the subject at increased risk of harm if they were to participate.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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The Center for Applied Health Sciences
RECRUITINGCanfield, Ohio, 44406, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Study tests if menopause changes how women rehydrate
- Morning eating and exercise may shield older women from muscle loss
- Vaginal estrogen vs DHEA: which eases menopause discomfort better?
- Beetroot boost: simple juice may supercharge workouts for women after menopause
- Progesterone showdown: are two injections equally effective?
- Walking vs. weights: which exercise helps blood sugar in menopausal women with type 1 diabetes?