Placenta patch put to the test for faster mouth healing
NCT ID NCT07824596
First seen Sep 17, 2026 · Last updated Sep 18, 2026 · Updated 1 time
Summary
Surgeons often take a small piece of tissue from inside the mouth to rebuild the urethra in men with a narrowed urine tube. This leaves a raw patch in the mouth that can be painful and slow to heal. Researchers are testing whether covering that mouth wound with a biological dressing made from amniotic membrane helps it close faster and hurt less than leaving it to heal on its own. The trial enrolls 58 adults and tracks healing, pain, mouth opening, and quality of life.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- amniotic membrane used as a biological dressing on the mouth wound
- What this could lead to
- If it works, this could give surgeons a simple way to speed mouth healing and reduce pain after graft harvest, making urethral reconstruction easier to recover from.
- What could go wrong
- The trial is small and single-center, so results may not apply broadly. Amniotic membrane dressings can also carry a small risk of infection or rejection, and healing may not improve more than standard care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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58 people
The number who actually took part.
- Started
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Jun 2025
- Finished
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May 2026
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Male participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients were eligible for inclusion if they met the following criteria: * Adult patients (≥18 years) * Diagnosed with anterior urethral stricture requiring substitution urethroplasty * Planned use of buccal mucosal graft for urethral reconstruction * Ability to provide informed consent and comply with follow-up protocol Exclusion Criteria: * Patients were excluded if they had: * Previous buccal mucosal graft harvest * Active oral infection or mucosal pathology * History of oral malignancy or radiotherapy * Uncontrolled systemic disease (e.g., poorly controlled diabetes mellitus) * Immunosuppression or chronic steroid use * Known allergy to biological graft materials
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Zagazig University
Zagazig, Egypt