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Placenta patch put to the test for faster mouth healing

NCT ID NCT07824596

Symptom relief Sponsor: Zagazig University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 17, 2026 · Last updated Sep 18, 2026 · Updated 1 time

Summary

Surgeons often take a small piece of tissue from inside the mouth to rebuild the urethra in men with a narrowed urine tube. This leaves a raw patch in the mouth that can be painful and slow to heal. Researchers are testing whether covering that mouth wound with a biological dressing made from amniotic membrane helps it close faster and hurt less than leaving it to heal on its own. The trial enrolls 58 adults and tracks healing, pain, mouth opening, and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
amniotic membrane used as a biological dressing on the mouth wound
What this could lead to
If it works, this could give surgeons a simple way to speed mouth healing and reduce pain after graft harvest, making urethral reconstruction easier to recover from.
What could go wrong
The trial is small and single-center, so results may not apply broadly. Amniotic membrane dressings can also carry a small risk of infection or rejection, and healing may not improve more than standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

58 people

The number who actually took part.

Started

Jun 2025

Finished

May 2026

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients were eligible for inclusion if they met the following criteria: * Adult patients (≥18 years) * Diagnosed with anterior urethral stricture requiring substitution urethroplasty * Planned use of buccal mucosal graft for urethral reconstruction * Ability to provide informed consent and comply with follow-up protocol Exclusion Criteria: * Patients were excluded if they had: * Previous buccal mucosal graft harvest * Active oral infection or mucosal pathology * History of oral malignancy or radiotherapy * Uncontrolled systemic disease (e.g., poorly controlled diabetes mellitus) * Immunosuppression or chronic steroid use * Known allergy to biological graft materials

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Conditions

The condition(s) this trial relates to.

urethral stricture

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Buccal mucosal defect

Contacts and locations

Locations

  • Zagazig University

    Zagazig, Egypt