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Dental implant bone loss: which membrane heals better?

NCT ID NCT07032259

Disease control Sponsor: Loma Linda University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study compares two barrier materials used in surgery to repair bone loss around dental implants: a membrane made from donated birth tissue (amnion-chorion) and a standard collagen membrane. Fifty-six adults with peri-implantitis (infection and bone loss around an implant) will receive one of the two membranes during guided bone regeneration. The goal is to see which material reduces pocket depth and fills in bone better, and how patients feel after surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 56 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2026

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Systemically healthy adults (≥18 years) with a diagnosed peri-implantitis lesion requiring surgical intervention of any ethnicity * Comprehension of treatment plan and research project. * Presence of a single implant in function for at least one year. * Radiographic evidence of peri-implant bone loss not exceeding one-third of the implant length. * 2-3 wall defects amenable to guided bone regeneration (GBR). * Screw-retained, posterior, self-cleansing implant prosthesis. * Commitment to maintaining oral hygiene and attending follow-up visits. Exclusion Criteria: * Patients who have had a history of periodontitis, diabetes, smoking habit, or have been prescribed medications that may interfere with bone healing and metabolism * Patients with allergies to any treatment devices * Patients who have a lack of keratinized mucosa (\<2 mm), or positioning for implants or restorative designs that compromise oral hygiene * Peri-implant bone defects not attributable to peri-implantitis (e.g. surgical iatrogenic, trauma) * Anterior implant restorations (#'s 6-11, #'s 22-27) or cement-retained restorations

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Conditions

The condition(s) this trial relates to.

Peri-Implantitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Peri-implantitis

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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