New drug combo shows promise against lung cancer brain metastases

NCT ID NCT04965090

Completed Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jan 06, 2026 · Last updated May 24, 2026 · Updated 20 times

Summary

This study tested two drugs, amivantamab and lazertinib, in 43 adults with a specific type of lung cancer (EGFR-mutant) that had spread to the brain and was getting worse despite previous treatments. The goal was to see if the combination could shrink or control brain tumors. Both drugs target cancer cells with the EGFR mutation to slow or stop growth.

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Contacts and locations

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Locations

Memorial Sloan Kettering Basking Ridge

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Commack

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester

Harrison, New York, 10604, United States

Conditions

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METASTATIC NON-SMALL CELL LUNG CANCER RECURRENT NON SMALL CELL LUNG CANCER