Scientists probe muscle loss in ICU patients with novel tracer technique
NCT ID NCT03451968
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study aims to understand how amino acids are processed differently in critically ill patients who have been in the ICU for more than 7 days compared to healthy volunteers. Researchers will inject stable (non-radioactive) amino acid tracers and take multiple blood samples over 3 hours to measure metabolism. The goal is to gather knowledge that could eventually lead to better nutritional support or treatments to prevent muscle wasting in long-stay ICU patients.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- stable amino acid tracers (injected)
- What this could lead to
- If successful, this could help guide future treatments to prevent muscle wasting in long-term ICU patients.
- What could go wrong
- This is a small, early observational study with only 30 participants. It measures metabolism but does not test any treatment, so direct patient benefits are not expected.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 30 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Dec 2018
- Expected to finish
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Jan 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Study population: * 15 ICU critically ill patient hospitalized due to surgical/trauma injury. * above 18 years old no upper limit. * hospitalized at the ICU more than 7 days Control group: * 15 Healthy volunteers, over 18 years old no upper limit. * the volunteers won't be dependent or subordinated to the research investigators Exclusion Criteria: 1. patients under 18 years old 2. patients under TPN treatment prior to their admission to ICU 3. patients with chronic bowel disease (e.g Crohn's, celiac, short bowel) 4. any relation (e.g family member or assistant) to the study investigators
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Rabin medical center
RECRUITINGPetah Tikva, Israel
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