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Could a common cold drug stop chronic pain after chest surgery?

NCT ID NCT06833203

Symptom relief Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding amantadine (a drug used for flu and Parkinson's) to pregabalin (a nerve pain medication) can prevent chronic pain after chest surgery. Sixty cancer patients having chest surgery took either both drugs or pregabalin alone for five days. Researchers then checked for pain 12 weeks later and measured quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Amantadine and Pregabalin
What this could lead to
If it works, this combination could help prevent long-term pain after chest surgery, improving recovery and quality of life.
What could go wrong
This is a small, completed trial with only 60 participants. Results may not apply to everyone, and the benefit over pregabalin alone may be small or absent.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

Dec 2023

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age (18-65) years. * Both sexes. * American Society of Anesthesiologists (ASA) Physical status II, III. * Body mass index (BMI): (20-40) kg/m2. * Cancer patients undergoing posterolateral thoracotomy incision for cancer lung, mesothelioma or other lung resection procedures. Exclusion Criteria: * Patients with known sensitivity or contraindication to drug used in the study. * History of psychological disorders and/or chronic pain and drug abuse patients. * Previous administration of antidepressants, anticonvulsants, or opioids before surgery. * Patient refusal. * Severe respiratory or cardiac disorders. * Advanced liver or kidney disease.

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Conditions

The condition(s) this trial relates to.

lung cancer mesothelioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Amantadine Post-thoracotomy pain syndrome Pregabalin

Contacts and locations

Locations

  • Cairo University

    Cairo, Cairo Governorate, 12613, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.