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New scan could spot Alzheimer's hallmark before death

NCT ID NCT05641688

Diagnosis Sponsor: Lantheus Biosciences Ltd. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a special PET scan using [18F]PI-2620 to see if it can accurately detect tau tangles in the brains of people with Alzheimer's disease. About 200 adults aged 50 and older with a short life expectancy will get the scan. After they pass away, researchers will compare the scan results to actual brain tissue samples to see how well the scan works.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2022

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Only subjects who meet all of the following criteria will be eligible for enrollment into the study: 1. Males and females aged 50 years and over 2. Have a projected life expectancy of ≤ 1 year as determined by the investigator (terminal medical condition including but not limited to end-stage dementia, end-stage congestive heart failure, end-stage chronic obstructive pulmonary disease (COPD), or end-stage cancer) 3. Written informed consent obtained from the subject and/or the subject's legally authorized representative (LAR), as applicable, to consent for study procedures and brain donation (consent consistent with the legal requirements of the State in which the subject dies) 4. Can tolerate study procedures including lying down in PET scanner. The investigator will carefully assess each subject and use medical judgment to determine whether the subject can tolerate the imaging procedure Exclusion Criteria: Subjects will be excluded from the enrollment if they: 1. Are receiving aggressive treatment with life sustaining measures (e.g. receiving chemotherapy; palliative chemotherapy is allowed) 2. Are known to have a structural brain lesion that would interfere either with PET imaging or pathological assessment (e.g. lesions are typically \> 2 cm at their greatest extent and may include stroke, primary or metastatic neoplasm, other tumors or cystic lesions. Subjects with a history of major stroke or traumatic brain injury or other structural lesion as well as cases with a history of primary Central Nervous System (CNS) neoplasm or known metastatic cancer must be discussed with the study sponsor prior to enrollment) 3. Have suspected encephalopathy due to alcoholism or end-stage liver disease 4. Are known to have a Glomerular Filtration Rate below \< 15 mL/min 5. Have received an investigational or approved therapy directly targeting amyloid or tau 6. Are females of childbearing potential who are pregnant, lactating or breastfeeding, or who are not using adequate contraception 7. Have implants such as implanted cardiac pacemakers or defibrillators, insulin pumps, cochlear implants, metallic ocular foreign body, implanted neural stimulators, CNS aneurysm clips and other medical implants that have not been certified for MRI, or history of claustrophobia in MRI (in case an MRI is planned to be performed)

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Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alzheimer disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    20 sites. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Email: •••••@•••••

Locations

  • Alzheimer's Disease Center

    RECRUITING

    Braintree, Massachusetts, 02184, United States

  • American Carolina Clinical Research LLC

    TERMINATED

    Charlotte, North Carolina, 28273, United States

  • Banner Sun Health Research Institute

    RECRUITING

    Sun City, Arizona, 85352, United States

  • Barrow Neurological Institute

    RECRUITING

    Phoenix, Arizona, 85013, United States

  • Baylor Research Institute

    RECRUITING

    Dallas, Texas, 75231, United States

  • Be Well Clinical Studies

    WITHDRAWN

    Lincoln, Nebraska, 68616, United States

  • Be Well Clinical Studies

    RECRUITING

    Round Rock, Texas, 78681, United States

  • Charter Research

    RECRUITING

    Winter Park, Florida, 32792, United States

  • ClinCloud Research

    RECRUITING

    Melbourne, Florida, 32940, United States

  • Darthmouth-Hitchcock Medical Center

    RECRUITING

    Lebanon, New Hampshire, 07366, United States

  • Esperanza Clinical

    RECRUITING

    Murrieta, California, 92562, United States

  • Galiz Research

    RECRUITING

    Hialeah, Florida, 33016, United States

  • Headlands Research

    WITHDRAWN

    Plymouth, Massachusetts, 02360, United States

  • Ichor Research

    RECRUITING

    Syracuse, New York, 13219, United States

  • Insight Clinical Trials LLC

    RECRUITING

    Beachwood, Ohio, 44131, United States

  • K2 Medical Research

    RECRUITING

    Lady Lake, Florida, 32159, United States

  • K2 Medical Research

    RECRUITING

    Maitland, Florida, 32751, United States

  • Miami Jewish Health Systems

    RECRUITING

    Miami, Florida, 33137, United States

  • Sante Clinical Research

    RECRUITING

    Kerrville, Texas, 78028, United States

  • Sutter Health

    RECRUITING

    San Francisco, California, 94114, United States

  • The Roskamp Institute

    TERMINATED

    Sarasota, Florida, 34243, United States

  • UC Los Angeles

    RECRUITING

    Los Angeles, California, 90095 - 7370, United States

  • UF College of Medicine - Jacksonville

    WITHDRAWN

    Jacksonville, Florida, 32209, United States

  • Valley Medical Research

    RECRUITING

    Centerville, Ohio, 45459, United States

  • Velocity Clinical Research

    RECRUITING

    East Syracuse, New York, 13057, United States

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