Alzheimer's swallowing troubles: new study seeks answers
NCT ID NCT06678100
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study compares swallowing function in older adults with and without Alzheimer's disease. Researchers will also survey caregivers to understand the burden of swallowing issues. Participants will undergo tests of swallowing, coughing, and muscle strength. The goal is to learn more about when and how swallowing problems develop in Alzheimer's.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could help doctors better understand and predict swallowing problems in Alzheimer's disease, potentially improving care and quality of life.
- What could go wrong
- This is an observational study, not a treatment trial. It will not directly change how Alzheimer's is treated, and results may not apply to everyone with the disease.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
About 240 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Apr 2025
- Expected to finish
-
Feb 2028
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The overall objective of this proposal is to evaluate swallow function in 80 healthy adults and 80 individuals with AD and to evaluate caregiver perceptions of swallow function and burden in 80 caregivers of individuals with AD. Thus, this study will enroll healthy adults, individuals with AD, and caregivers of individuals with AD.
- Ages
-
60 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion criteria for AD cohort: 1. adult ≥60 years old 2. diagnosis of AD by a neurologist (confirmed with imaging, spinal tap, behavioral testing) 3. no prior history of other neurological diseases (aside from stroke which has resolved with no current symptoms) 4. no prior history of respiratory diseases 5. no prior history of head and neck surgery/head and neck cancer/radiation to head and neck region 6. consuming some form of oral intake 7. able to follow basic directions 8. able/willing to provide consent/assent. Exclusion Criteria for AD Cohort: 1. individual \<60 years old 2. Diagnosis of another type of dementia 3. History of neurological/respiratory diseases 4. History of head and neck surgery/head and neck cancer/radiation to head and neck region 5. not consuming any oral intake 6. Unable to follow basic directions 7. Unable to provide consent based on the University of California, San Diego Brief Assessment of Capacity to Consent (UBACC), score \<15 OR provide assent and a legal guardian/health care decision maker provides consent. Inclusion criteria for care partners of individuals with AD will be: 1. care partner of an individual with AD 2. willing to complete questionnaires/participate in an interview. Exclusion Criteria for Caregivers of Individuals with AD: 1. not the primary caregiver of an individual with AD 2. unwilling to complete questionnaires/semi-structured interview Inclusion criteria for community-dwelling adults will be: 1. adult ≥60 years old 2. no prior history of neurological diseases (aside from stroke which has resolved with no current symptoms) 3. no prior history of respiratory diseases 3\) no prior history of head and neck surgery/head and neck cancer/radiation to head and neck region 4) no prior history of swallowing difficulties based on participant report. 5) Score ≥25th percentile based on sex/age/education/race on the Montreal Cognitive Assessment (MOCA) Exclusion Criteria for Healthy Cohort: 1. individual \<60 years old 2. history of neurological disease 3. history of respiratory disease 4. history of head and neck surgery/head and neck cancer/radiation to head and neck region 5. history of swallowing difficulties 6. Score \<25th percentile based on sex/age/education/race on the Montreal Cognitive Assessment (MOCA)
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Alzheimer disease are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
1 site. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
Vanderbilt University Medical Center
RECRUITINGNashville, Tennessee, 37232, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a massive data registry crack the code of Parkinson's and related brain diseases?
- Can sharing old memories boost mental Well-Being in old age?
- Can a gentle electric current calm the mind in Alzheimer's?
- Alzheimer's vaccine aims to clear amyloid before memory fades
- Blood, eye, and brain scans team up to spot Alzheimer's earlier
- 150,000 children to be tracked from birth to old age in massive health study