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Hidden liver harm: study seeks answers for rare disease

NCT ID NCT02014415

First seen Apr 30, 2026 · Last updated May 21, 2026 · Updated 4 times

Summary

This study looks at adults with Alpha-1 Antitrypsin Deficiency, a genetic condition that can cause lung and liver problems. Researchers want to find out how often liver damage occurs without symptoms and what genetic or environmental factors play a role. About 120 participants will be followed for up to 5 years with liver biopsies and other tests. The goal is to better understand and identify liver disease early in this condition.

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Contacts and locations

Locations

  • Boston University School of Medicine

    Boston, Massachusetts, 02118, United States

  • Saint Louis University

    St Louis, Missouri, 63104, United States

  • University of California

    San Diego, California, 92103, United States

Conditions

Explore the condition pages connected to this study.