Rare gene defect may fuel liver cancer in otherwise healthy livers

NCT ID NCT07145385

Not yet recruiting Knowledge-focused Sponsor: University Hospital, Bordeaux Source: ClinicalTrials.gov ↗

First seen Jan 11, 2026 · Last updated Jun 18, 2026 · Updated 26 times

Summary

This study aims to find out how often a rare genetic condition called alpha-1 antitrypsin deficiency (AATD) occurs in people who develop liver cancer (hepatocellular carcinoma) but do not have cirrhosis or other known causes like hepatitis or heavy drinking. Researchers will look back at medical records of 71 adults with this type of liver cancer to see if AATD is a hidden risk factor. The results could help identify a new cause for some liver cancers.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for RETROSPECTIVE COHORT OF PATIENTS DIAGNOSED WITH HCC ON NON-CIRRHOTIC LIVER are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

CHU Bordeaux

Bordeaux, France

Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

The condition(s) this trial relates to.

alpha 1-antitrypsin deficiency hepatocellular carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RETROSPECTIVE COHORT OF PATIENTS DIAGNOSED WITH HCC ON NON-CIRRHOTIC LIVER