Could donated fat ease arthritis in your hands?
NCT ID NCT05747469
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial is testing whether injecting donated fat tissue into the small joints of the hand can reduce pain and improve movement in people with hand osteoarthritis. About 34 adults with joint pain and X-ray evidence of arthritis will receive the injection under local anesthesia. Researchers will measure changes in strength, range of motion, pain, and disability over time.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- donated fat tissue (allograft adipose matrix)
- What this could lead to
- If it works, this could offer a simple, off-the-shelf injection to reduce hand pain and disability without needing surgery or the patient's own fat.
- What could go wrong
- This is a very early, small trial with only 34 people, so results may not apply widely. The treatment is still experimental and safety and effectiveness are not yet proven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Early phase 1
The earliest testing in people: a first look at safety, in a very small group.
- Participants
-
34 people
The number who actually took part.
- Started
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Aug 2023
- Expected to finish
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Jan 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients greater than 18 years, with presentation to the Cedars Sinai hand clinic for joint pain of the hand carpometacarpal, interphalangeal, proximal interphalangeal, and distal interphalangeal joints (CMC, IP, PIP or DIP joints). * Radiographic evidence of osteoarthritis. Exclusion Criteria: * Prior intervention for the presenting joint (either in the form of cortisone or hyaluronic acid injection or surgery). * Rheumatoid or other inflammatory arthritis condition * Collagen vascular disease * Pregnancy or breast-feeding * Congestive heart failure * Chronic obstructive pulmonary disease * Chronic renal failure * Those who had medication or oral supplements for the previous 4 weeks that could prolong bleeding time (e.g.; Aspirin, Plavix).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Cedars-Sinai Medical Center
Los Angeles, California, 90048, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.