Pill combo could replace harsh chemo for High-Risk leukemia
NCT ID NCT04817241
First seen Nov 10, 2025 · Last updated May 23, 2026 · Updated 25 times
Summary
This study tests a new all-oral treatment (ASTX727 plus venetoclax) against standard IV chemotherapy for younger adults (18-65) with high-risk acute myeloid leukemia (AML) that lacks a FLT3 mutation. The goal is to see if the pill combo is safer and works as well or better. Only 5 people enrolled so far, and the study is active but not recruiting.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Montefiore Medical Center - Moses Campus
The Bronx, New York, 10467, United States
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Montefiore Medical Center-Einstein Campus
The Bronx, New York, 10461, United States
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Roswell Park Cancer Institute
Buffalo, New York, 14263, United States
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University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, 35233, United States
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University of Virginia Cancer Center
Charlottesville, Virginia, 22908, United States
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Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, 37232, United States
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Yale University
New Haven, Connecticut, 06520, United States
Conditions
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