Which opioid keeps surgery smoother? a Head-to-Head test
NCT ID NCT07761312
First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time
Summary
This trial asks whether alfentanil, an opioid painkiller, works as well as the standard remifentanil during general anesthesia for surgery. About 990 adults having non-cardiac, non-brain surgery will be randomly assigned to receive one of the two drugs through an IV. Researchers will track how often extra medications are needed to control pain or blood pressure during the operation, and how quickly patients wake up and recover afterward. The goal is to see if alfentanil can match remifentanil's performance, potentially offering another safe option for smoother surgeries and faster recovery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- alfentanil (an opioid pain medication given during general anesthesia)
- What this could lead to
- If alfentanil works as well as remifentanil, it could offer a safer or more cost-effective option for managing pain during surgery, potentially improving recovery experiences.
- What could go wrong
- This is a phase 4 trial, but results may still vary. Alfentanil might not be as effective in all patients, and any opioid carries risks like nausea, vomiting, or breathing problems.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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About 990 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Sep 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria:(1) Age between 18 and 65 years, with no gender restriction; (2) BMI ≥ 18 kg/m²; (3) ASA classification I-III; (4) Elective surgeries that are not related to the chest or brain, with an anticipated duration of 60-240 minutes; (5) Anticipated blood loss \< 500 mL; (6) Voluntary consent to sign the Informed Consent Form. Exclusion Criteria:(1) Abuse or long-term use of opioid medications; (2) Severe hepatic and renal dysfunction (ALT/AST \> 2×ULN, Cr \> 176 μmol/L); (3) Serious cardiovascular diseases, including but not limited to: Severe cardiac arrhythmias or conduction abnormalities, such as ventricular arrhythmias requiring clinical intervention, second- or third-degree atrioventricular block, or uncontrolled atrial fibrillation; a history of acute myocardial infarction, unstable angina pectoris within the past 6 months, or having undergone coronary stenting or coronary artery bypass surgery. Congestive heart failure classified as NYHA Class II or above, or left ventricular ejection fraction (LVEF) \< 50%. (4) A history of cerebrovascular accidents (including ischemic and hemorrhagic strokes) or transient ischemic attacks within the past 6 months; (5) Uncontrolled severe hypertension: resting systolic blood pressure ≥ 160 mmHg and/or diastolic blood pressure ≥ 100 mmHg (confirmed by repeated measurements); (6) Symptomatic aortic dissection, or lower limb arterial occlusion requiring treatment.(4) Severe blood system disorders, including but not limited to severe anemia, aplastic anemia, acute leukemia, thrombotic thrombocytopenic purpura, etc. (5) Difficulty in predicting airway management; (6) Pregnancy or lactation; (7) Allergy to opioids/propropofol/eggs/soybeans; (8) Participation in other clinical trials within the past 3 months. \-
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.