Which opioid keeps surgery smoother? a Head-to-Head test
NCT ID NCT07761312
First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time
Summary
This trial asks whether alfentanil, an opioid painkiller, works as well as the standard remifentanil during general anesthesia for surgery. About 990 adults having non-cardiac, non-brain surgery will be randomly assigned to receive one of the two drugs through an IV. Researchers will track how often extra medications are needed to control pain or blood pressure during the operation, and how quickly patients wake up and recover afterward. The goal is to see if alfentanil can match remifentanil's performance, potentially offering another safe option for smoother surgeries and faster recovery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- alfentanil (an opioid pain medication given during general anesthesia)
- What this could lead to
- If alfentanil works as well as remifentanil, it could offer a safer or more cost-effective option for managing pain during surgery, potentially improving recovery experiences.
- What could go wrong
- This is a phase 4 trial, but results may still vary. Alfentanil might not be as effective in all patients, and any opioid carries risks like nausea, vomiting, or breathing problems.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.