Anti-aging pill? singapore trial tests AKG on biological age

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * participants whose biological age (as measured by blood DNA methylation) is greater than their chronological age Exclusion Criteria: * pregnant women * more than ONE of the following chronic medical conditions (based on the medical history and during screening), they are NOT eligible to participate in the study: 1. Waist circumference more than or equal to 90 cm for males or more than or equal to 80 cm for females 2. Fasting triglycerides more than or equal to 1.7 mmol/l 3. High-density lipoprotein less than 1.0 mmol/l in men or less than 1.3 mmol/l in women 4. Blood pressure more than or equal to 130/85 mmHg or use of antihypertensive medication 5. Fasting glucose more than or equal to 6.0 mmol/l 6. Osteopenia 7. Mild Osteoarthritis not interfering in daily activities 8. Fatty liver * Participants will NOT be recruited if they fall in the following categories: 1. Pre-existing, or history of major CVD (coronary artery disease, heart failure, stroke, peripheral vascular disease, pulmonary hypertension), severe/uncontrolled hypertension (under 3 or more than 3 prescribed medications), rheumatic heart disease, congenital heart disease, deep vein thrombosis, pulmonary embolism 2. Type 1 diabetes and Type 2 diabetes under oral metformin or insulin therapy and with diabetic complications such as diabetic retinopathy, diabetic nephropathy 3. Active cancer or treatment of cancer in the last 3 years 4. Chronic obstructive pulmonary disease (COPD), severe asthma (taking daily medications) 5. Pregnant women will not be recruited into this study because of the safety issues associated with X-ray irradiation during DXA scan 6. Potential female participants who plan on pregnancy within the next 9 months of study period 7. Multiple sclerosis and autoimmune/immune deficiency diseases such as Rheumatic arthritis, HIV, Crohn's disease 8. Recent history of sepsis or infection (within 3 months of in-patient hospitalization) 9. Any psychiatric disease or neurodegenerative diseases such as Alzheimer's Disease, Parkinson's Disease, Lewy body dementia, and any eating disorders 10. Any metal implants in the body 11. Hepatitis and Liver cirrhosis (independent of severity) 12. Severe kidney disease (GFR less than 30 ml/min/1.73 m2) 13. Skin disease (on oral or systemic medication for immune system) 14. Subjects receiving any other similar investigational product within 60 days or 5 halflives before the screening, whichever that is longer 15. Any serious medical illness which in the PI's judgment may jeopardize the subject by his or her participation in this study or may hamper his or her ability to perform and complete procedures required in the study