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New study aims to uncover hidden lung danger in ventilator patients

NCT ID NCT07512713

Knowledge-focused Sponsor: University Hospital, Clermont-Ferrand Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how often the airways close in critically ill adults who need a breathing machine (ventilator) in the ICU. About 500 patients across 39 ICUs will have a simple bedside test to check for airway closure. The goal is to learn more about this common but under-recognized issue, which can affect how doctors set the ventilator and may lead to lung injury. No changes to patient care will be made; this is purely an observation study.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 500 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2026

An estimate. Start dates often move.

Expected to finish

Feb 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Eligible patients will be prospectively included over a period of two weeks (14 consecutive days) in 38 intensive care units in France.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years old * Patients admitted to a participating ICU * Patients receiving invasively ventilation for any cause We will only include patients under controlled mechanical ventilation because airway closure is difficult to assess in spontaneously breathing patients. Non-inclusion Criteria: * A patient admitted to hospital or transferred to the intensive care unit without a documented time of intubation * Have a tracheotomy/tracheostomy at the time of inclusion * Are receiving an assist ventilation mode * Patient or relative's refusal to participate for data collection * Pregnant or breast-feeding women * Legal protection (i.e., patient under a tutelage, or curatorship, or placed under judicial incarceration)

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

In adults in intensive care Mechanical ventilation in controlled mode Prevalence of airway closure

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • CHU de Clermont-Ferrand

    Clermont-Ferrand, France