New plasma and gas combo may fight deadly heart surgery infections
NCT ID NCT04617353
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a combined treatment using air-plasma flow and nitric oxide gas to prevent and treat wound infections after heart surgery. It included 80 patients with mediastinitis, a serious chest infection. The goal was to see if this approach could reduce infection, improve wound healing, and lower death rates.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- air-plasma flow and nitric oxide therapy
- What this could lead to
- If successful, this could offer a new way to prevent and treat serious wound infections after heart surgery, potentially reducing complications and deaths.
- What could go wrong
- This is a small, completed study with 80 participants, so results may not apply to all patients. The treatment is a procedure, not a drug, and its effectiveness compared to standard care is uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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80 people
The number who actually took part.
- Started
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Mar 2017
- Finished
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Dec 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients who underwent heart and great vessels surgery with confirmed laboratory, bacteriological, instrumental tests, as well as the presence of clinical signs of sterno-mediastinitis. * Signed informed consent to participate in the study Exclusion Criteria: * Patients who underwent heart and great vessels surgery not through a median sternotomy. * Patients who have signs of inconsistency of sutures or any other wound complications, but there are no clinical, laboratory, bacteriological data indicating infection of the postoperative wound. * No informed consent to participate in the study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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TomskNRMC
Tomsk, Tomskay Oblast, 634012, Russia
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