AI takes on hip surgeons in diagnosis showdown
NCT ID NCT07012577
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether GPT-4, an AI language model, can diagnose and recommend treatments for failed hip replacements as well as human surgeons. Researchers presented 20 anonymized patient cases to GPT-4 and three surgeons with different experience levels. The goal is to see if AI could become a helpful tool in orthopedic decision-making.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- GPT-4 (an advanced AI language model)
- What this could lead to
- If successful, this could show that AI can assist doctors in diagnosing and treating failed hip replacements, potentially improving decision-making.
- What could go wrong
- This is a small, early study with only 20 cases. AI may not match human expertise in complex real-world scenarios, and results may not apply broadly.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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20 people
The number who actually took part.
- Started
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May 2025
- Finished
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Jul 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
This study evaluated 20 anonymized cases of failed/painful total hip arthroplasty (2004-2024) from a tertiary center. Cases were selected for diagnostic clarity (e.g., aseptic loosening, periprosthetic fracture) and excluded if records were incomplete or ambiguous. Two senior surgeons verified case eligibility. Each case was assessed by GPT-4, an arthroplasty fellow, a 4th-year resident, and a 3rd-year resident for diagnostic/therapeutic accuracy.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults (≥18 and ≤80 years old). * Documented painful or failed total hip arthroplasty requiring clinical/radiological evaluation (2004-2024). * Complete pre-operative clinical history, imaging (X-ray/tomography), and surgical reports. * Clear diagnosis of failure mode (e.g., aseptic loosening, infection, fracture, wear). * Treatment and outcomes fully documented in the institutional database. * "Exemplary" cases with minimal diagnostic ambiguity (per Engh/MusculoSkleletal Infection Society criteria, etc.). Exclusion Criteria: * total hip arthroplasty with no documented failure/pain (well-functioning implants). * Incomplete clinical/radiological records (e.g., missing pre-operative imaging or surgical notes). * Complex/multifactorial failures (e.g., concurrent infection + loosening + fracture). * Radiographs/images non-interpretable (poor quality, missing views). * Cases with conflicting diagnoses/treatments in original records.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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SC Ortopedia e Traumatologia e Chirurgia Protesica e dei Reimpianti di Anca e Ginocchio, IRCCS Istituto Ortopedico Rizzoli
Bologna, Italy, 40136, Italy
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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