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AI takes on hip surgeons in diagnosis showdown

NCT ID NCT07012577

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether GPT-4, an AI language model, can diagnose and recommend treatments for failed hip replacements as well as human surgeons. Researchers presented 20 anonymized patient cases to GPT-4 and three surgeons with different experience levels. The goal is to see if AI could become a helpful tool in orthopedic decision-making.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
GPT-4 (an advanced AI language model)
What this could lead to
If successful, this could show that AI can assist doctors in diagnosing and treating failed hip replacements, potentially improving decision-making.
What could go wrong
This is a small, early study with only 20 cases. AI may not match human expertise in complex real-world scenarios, and results may not apply broadly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

20 people

The number who actually took part.

Started

May 2025

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This study evaluated 20 anonymized cases of failed/painful total hip arthroplasty (2004-2024) from a tertiary center. Cases were selected for diagnostic clarity (e.g., aseptic loosening, periprosthetic fracture) and excluded if records were incomplete or ambiguous. Two senior surgeons verified case eligibility. Each case was assessed by GPT-4, an arthroplasty fellow, a 4th-year resident, and a 3rd-year resident for diagnostic/therapeutic accuracy.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults (≥18 and ≤80 years old). * Documented painful or failed total hip arthroplasty requiring clinical/radiological evaluation (2004-2024). * Complete pre-operative clinical history, imaging (X-ray/tomography), and surgical reports. * Clear diagnosis of failure mode (e.g., aseptic loosening, infection, fracture, wear). * Treatment and outcomes fully documented in the institutional database. * "Exemplary" cases with minimal diagnostic ambiguity (per Engh/MusculoSkleletal Infection Society criteria, etc.). Exclusion Criteria: * total hip arthroplasty with no documented failure/pain (well-functioning implants). * Incomplete clinical/radiological records (e.g., missing pre-operative imaging or surgical notes). * Complex/multifactorial failures (e.g., concurrent infection + loosening + fracture). * Radiographs/images non-interpretable (poor quality, missing views). * Cases with conflicting diagnoses/treatments in original records.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • SC Ortopedia e Traumatologia e Chirurgia Protesica e dei Reimpianti di Anca e Ginocchio, IRCCS Istituto Ortopedico Rizzoli

    Bologna, Italy, 40136, Italy

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