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AI may match depression patients to the right therapy faster

NCT ID NCT06567340

Disease control Sponsor: Rotherham Doncaster and South Humber NHS Foundation Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time

Summary

This trial tests whether an artificial intelligence tool called StratCare can improve depression treatment by recommending personalized therapy paths. About 1,250 adults with depression will be split into two groups: one using StratCare to guide treatment choice, the other following standard stepped care. Researchers will track mood and quality of life over 18 months to see if the AI-driven approach leads to better recovery rates.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
StratCare, an AI-driven decision-support tool that recommends personalized depression treatment pathways
What this could lead to
If it works, StratCare could help more people recover from depression by matching them to the right therapy from the start.
What could go wrong
The trial is large but still tests a single AI tool in one healthcare system; results may not apply elsewhere, and the algorithm's recommendations may not suit everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 1,252 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

In addition to the criteria, participants must be under the treatment of a participating Talking Therapies service. Inclusion criteria: * 18 years of age or older. * Patients who consent to share their de-identified clinical records for research purposes. * Patients assessed as eligible for psychological care in Talking Therapies based on clinical guidelines. * Patients with case-level depression symptoms (PHQ-9 ≥ 10). Exclusion Criteria: • Those who are ineligible for treatment in Talking Therapies services according to standard treatment guidelines.

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Conditions

The condition(s) this trial relates to.

anxiety disorder Depression depressive disorder mood disorder Psychological Well-Being

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Depression

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    10 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Central and Nort h West London NHS Foundation Trust

    RECRUITING

    London, NW1 3AX, United Kingdom

  • Cheshire and Wirral Partnership NHS Foundation Trust

    RECRUITING

    Chester, CH2 1BQ, United Kingdom

  • Homerton Healthcare NHS Foundation Trust

    RECRUITING

    London, E9 6SR, United Kingdom

  • Lancashire and South Cumbria NHS Foundation Trust

    RECRUITING

    Preston, Lancashire, PR5 6AW, United Kingdom

  • Rotherham Doncaster and South Humber NHS Foundation Trust

    RECRUITING

    Doncaster, South Yorkshire, DN4 8QN, United Kingdom

  • Somerset NHS Foundation Trust

    RECRUITING

    Taunton, Somerset, TA1 5DA, United Kingdom

  • Surrey and Borders Partnership NHS Foundation Trust

    RECRUITING

    Leatherhead, Surrey, KT22 7AD, United Kingdom

  • Tees, Esk and Wear Valleys NHS Foundation Trust

    RECRUITING

    Darlington, Durham, DL2 2TS, United Kingdom

  • Vita Health Group

    RECRUITING

    Nottingham, Nottinghamshire, United Kingdom

  • West London NHS Trust

    RECRUITING

    Southall, London, UB2 4SD, United Kingdom

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