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Can a new injection smooth away forehead lines?

NCT ID NCT07730554

Symptom relief Sponsor: AbbVie Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 28, 2026 · Last updated Aug 21, 2026 · Updated 2 times

Summary

This trial tests an experimental injection called AGN-151586 for adults with moderate to severe forehead lines. The goal is to see if the treatment is safe and can reduce the appearance of these wrinkles. Participants receive the injection and are monitored for side effects and changes in wrinkle severity.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
an injection of a drug called AGN-151586
What this could lead to
If it works, this could offer a new option for temporarily smoothing forehead wrinkles.
What could go wrong
This is an early phase 2 trial with only 80 people, so results may not apply to everyone. Side effects from injections are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participant must have moderate (Grade 2) or severe (Grade 3) forehead lines (FHL) at maximum eyebrow elevation as assessed by the subject and investigator using Forehead Lines Severity Scale (FHLSS) at Screening visit and Baseline Day 1 visit. * Participant must have moderate (Grade 2) or severe (Grade 3) glabellar lines (GL) at maximum frown as assessed by the subject and investigator using Allergan Glabellar Lines Severity Scale (AGLSS) at Screening visit and Baseline Day 1 visit. * Sufficient visual acuity without the use of eyeglasses (contact lens use is acceptable) to accurately assess their FHL and GL in investigator's opinion. Exclusion Criteria: * Clinically relevant or significant ECG abnormalities. * Active infection or dermatological condition at any of the treatment injection sites.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Forehead lines

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    5 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Austin Institute for Clinical Research - Pflugerville /ID# 282195

    RECRUITING

    Pflugerville, Texas, 78660, United States

  • Eye Research Foundation /ID# 282193

    RECRUITING

    Newport Beach, California, 92663, United States

  • Luxurgery /ID# 282336

    RECRUITING

    New York, New York, 10021, United States

  • Private Practice - Dr. Steven G. Yoelin /ID# 282334

    RECRUITING

    Newport Beach, California, 92663, United States

  • Wilmington Dermatology Center /ID# 282192

    RECRUITING

    Wilmington, North Carolina, 28403, United States

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