Can a serum reverse skin sagging from weight loss drugs?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Presence of mild to moderate signs of facial aging (e.g., fine lines, laxity, dull texture) based on modified Griffith scale. 2. Adult men and women aged 25-50 years. 3. Fitzpatrick skin types I-IV. 4. Current treatment with a stable dose of GLP-1 agonist medication, including Ozempic, Rybelsus, or Wegovy for at least last 6 months. 5. Must be willing to sign a photography release and ICF, and complete the entire course of the study. 6. Subjects in good general health based on the investigator's judgment and medical history. 7. Negative urine pregnancy test result at the time of study entry (if applicable). 8. Subjects of childbearing potential must agree to use an effective method of birth control during the entire course of the study. All systemic birth control measures must be in consistent use for at least 30 days prior to study enrollment. A. Acceptable forms of birth control are: oral contraceptive pill, injection, implant, patch, vaginal ring, intrauterine device/coil, double-barrier methods (e.g., sponge, spermicide, or condoms). Abstinence and/or vasectomized partners must agree to a second acceptable method of birth control (double-barrier) should the subject become sexually active. B. A female is considered of non-childbearing potential if she is: postmenopausal (no menses for at least 12 months), without a uterus (hysterectomy) and/or both ovaries (oophorectomy), or bilateral tubal ligation. Exclusion Criteria: 1. Pregnancy or planned pregnancy during the study or currently breastfeeding. 2. Current menopausal state. 3. Any uncontrolled systemic disease. 4. Current use of other GLP-1 agonist therapy aside from the GLP-1 agonist class of medications (Ozempic, Rybelsus, or Wegovy). 5. History of autoimmune connective tissue disease. 6. Current use of immunosuppressive medication. 7. Significant history or current evidence of a medical, psychological or other disorder that, in the investigator's opinion, would preclude enrollment into the study. 8. Active dermatitis or active infection in the proposed treatment area. 9. Mesotherapy; dermal fillers, biostimulator injectables; radiofrequency device treatments; microfocused ultrasound device treatments; laser and light-based device treatments; microneedling; cryolipolysis; high intensity focused electromagnetic energy device treatment; or surgery during the 12-month period before study treatment. 10. Creams/cosmeceuticals and/or home therapies for the prevention or treatment of skin quality in the treatment area during the 1-month period before study treatment. 11. Subjects with scarring in the treatment areas, which in the opinion of the investigator could impact results. Subjects with a history of keloids will be excluded. 12. Subjects who spray tanned or used sunless tanners in the treatment areas 1-month prior to study treatment. 13. History of bleeding disorder, concomitant use of anticoagulants, history of connective tissue disease (e.g., lupus, scleroderma), history of Bell's Palsy, epilepsy, smoking, and/or current pregnancy or breastfeeding. 14. Inability to ambulate following the procedure. 15. History of lidocaine and/or epinephrine sensitivity deemed by the investigator to preclude subject from enrolling into study. 16. Individuals with known allergies or sensitivities to any of the ingredients of any topical or injectable products being used in this study. 17. Current participation or participation within 30 days prior to the start of this study in a drug or other investigational research study.