New pill targets brain tumors with IDH mutations
NCT ID NCT02481154
First seen Feb 20, 2026 · Last updated Jun 16, 2026 · Updated 14 times
Summary
This early-phase study tested an oral drug called AG-881 in 95 adults with advanced solid tumors, including brain tumors (gliomas), that have specific IDH gene mutations. The main goals were to check safety, find the best dose, and see how the drug works in the body. While not a cure, it aims to control tumor growth by targeting the mutated IDH pathway.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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MD Anderson Cancer Center
Houston, Texas, 75390, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Sarah Cannon Research Institute
Nashville, Tennessee, 37203, United States
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UCLA Oncology Center
Los Angeles, California, 90024, United States
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UT Southwestern Medical Center
Dallas, Texas, 77030, United States
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University of California San Francisco
San Francisco, California, 94143, United States
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University of Miami
Miami, Florida, 33136, United States
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.