New imaging software could sharpen brain surgery planning
NCT ID NCT06191874
First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 1 time
Summary
This study tested a new imaging software called HoloDBS to see if it helps doctors plan deep brain stimulation (DBS) surgery better than current methods. Researchers reviewed medical records from 20 adults with Parkinson's disease who were already scheduled for DBS. No extra visits or treatments were involved—the goal was simply to compare the planned electrode location with the actual placement after surgery.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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22 people
The number who actually took part.
- Started
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Mar 2024
- Finished
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May 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients with Parkinson's disease scheduled for Deep Brain Stimulation Surgery
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Electronic medical records (EMR) from all patients undergoing preoperative DBS evaluation will be reviewed and their data will be used for this study's purposes if they fit the inclusion and exclusion criteria. Inclusion criteria: * age 18 years and over * meeting qualification for deep brain stimulation for Parkinson's disease with one or more of medication refractory tremor, motor fluctuations despite medication optimization, or levodopa responsiveness but limited by medication induced adverse effects (nausea, dystonia, dyskinesia for example). Exclusion criteria: * consideration of alternate diagnosis to Parkinson disease * high risk medical comorbidities which would make the patient not a candidate for surgery.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Duke University
Durham, North Carolina, 27708, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Could brain implants tame severe mental illness?
- Brain imaging may reveal who benefits from deep brain stimulation for Parkinson's freezing
- Brain implant for Parkinson's may raise fall risk — a study investigates
- Brain zap study reveals hidden motivation switches in Parkinson's
- Steering brain signals: new electrodes aim to ease Parkinson's symptoms