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Steering brain signals: new electrodes aim to ease Parkinson's symptoms

NCT ID NCT04578678

Disease control Sponsor: Insel Gruppe AG, University Hospital Bern Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether a newer type of deep brain stimulation (DBS) electrode, which can steer electrical signals more precisely, improves mood and movement in people with Parkinson's disease. 105 participants received the directional electrodes as part of their standard care. Researchers measured changes in non-motor symptoms and motor function over 12 months after surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

105 people

The number who actually took part.

Started

Aug 2019

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The project population consists of PD patients suffering from levodopa-responsive PD which are not adequately controlled by dopaminergic medication and therefore receive STN-DBS as a routine standard of care.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: For all subjects: * Informed consent as documented by signature * Diagnosis of PD based on the MDS clinical diagnostic criteria for Parkinson's disease * Fulfilling criteria for STN-DBS: * The presence of disabling motor complications of dopaminergic treatment * The absence of surgical contraindications * Planned bilateral STN-DBS using steering electrodes in the next 3 months (routine standard of care) Exclusion Criteria: * Presence of dementia as indicated by a score ≤ 25 on the MOntreal Cognitive Assessment (MOCA) * Depression with acute suicidal ideation * Presence of major ongoing psychiatric illness * Non-compensated systemic disease (i.e., diabetes, hypertension) * Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant * Participation in interventional trial within the 30 days preceding and during the present study * Previous enrolment into the current study * Enrolment of any study site personnel, their family members, employees or other dependent persons

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Conditions

The condition(s) this trial relates to.

Dysarthria Lethargy Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Deep brain stimulation Parkinson's disease

Contacts and locations

Locations

  • Hospices Civils de Lyon (Centre Hospitalier Universitaire de Lyon)

    Lyon, 69002, France

  • Hôpital Pitié-Salpêtrière

    Paris, 75013, France

  • Insel Gruppe AG University Hospital Bern

    Bern, 3010, Switzerland

  • Universitätsklinikum Würzburg

    Würzburg, 97080, Germany

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