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Could a shot of adrenaline replace the tourniquet in knee surgery?

NCT ID NCT07813715

Symptom relief Sponsor: Kathmandu University School of Medical Sciences Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 10, 2026 · Last updated Sep 11, 2026 · Updated 1 time

Summary

Knee arthroscopy lets surgeons see inside the joint through small cuts, and a clear view matters for safety and speed. Surgeons often use a thigh tourniquet to stop bleeding, but tourniquets can cause nerve pressure, muscle weakness, and delayed recovery. This study compares two ways to keep the surgical field bloodless: a standard tourniquet versus an injection of adrenaline (1:200,000) into the knee joint. Researchers will rate how well the surgeon can see and measure how much irrigation fluid is needed, in adults having ACL or meniscus surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
adrenaline injected into the knee joint
What this could lead to
If adrenaline works as well as a tourniquet, surgeons could avoid tourniquet-related nerve and muscle problems and patients might recover more comfortably after knee arthroscopy.
What could go wrong
This is a single-center cohort study of 169 people, so results may not apply everywhere. Adrenaline can affect heart rhythm and blood pressure, and it may not control bleeding as reliably as a tourniquet in every case.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

169 people

The number who actually took part.

Started

Jan 2023

Finished

Jul 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: \- Patients who are skeletally matured (18 year and above) undergoing knee arthroscopic surgeries. The surgeries included are: * Anterior Cruciate Ligament reconstruction * Anterior Cruciate Ligament repair * Anterior Cruciate Ligament decompression * Meniscus repair surgeries * Meniscus resection surgeries - Patients who provide consent for the study Exclusion Criteria: * The patient with following procedures are excluded: * Posterior Cruciate Ligament (PCL) surgeries * Multi-ligament surgeries * Osteochondral or intra articular fractures * Patients under 18 years of age * Patients who do not provide consent

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adrenaline Knee arthroscopy Outcome Tourniquet Visualization

Contacts and locations

Locations

  • Dhulikhel Hospital, Kathmandu University Hospital

    Dhulikhel, Bagmati, 45200, Nepal

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