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New study investigates why some women with adenomyosis suffer more pain

NCT ID NCT07455721

Knowledge-focused Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how the nervous system may become overly sensitive (central sensitization) in women with adenomyosis, a condition where uterine tissue grows into the muscle wall. Researchers will follow 1,200 women aged 18-50 for 12 months to see how common this sensitivity is and whether it affects pain and treatment success. The goal is to better understand pain patterns and improve care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Female patients aged 18 to 50 years attending the outpatient clinics of the participating centers, with an ultrasound diagnosis of adenomyosis (defined as having at least two MUSA criteria, including at least one direct feature), will be invited to participate in the present study.

Ages

18 to 50 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Ultrasound diagnosis of adenomyosis (previously established); * Acquisition of informed consent for participation in the study and for the processing of personal data. Exclusion Criteria: * Age \>18 years; * Age \<50 years; * Previous hysterectomy; * No prior vaginal sexual intercourse; * History of past or current gynecologic cancers; * History of neurological lesions or diseases that may negatively affect the central nervous system (e.g., brain or spinal cord injury, multiple sclerosis).

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Conditions

The condition(s) this trial relates to.

adenomyosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adenomyosis

Contacts and locations

Locations

  • AOR San Carlo

    Potenza, Potenza, 85100, Italy

  • ARNAS Ospedale Civico di Palermo

    Palermo, Palermo, 90127, Italy

  • IRCCS Azienda Ospedaliero-Universitaria di Bologna

    Bologna, Bologna, 40138, Italy

  • IRCCS Ca' Granda Ospedale Maggiore Policlinico

    Milan, Milano, 20122, Italy

  • IRCCS Ospedale San Raffaele di Milano

    Milan, Milano, 20132, Italy

  • Presidio Ospedaliero Universitario "Santa Maria della Misericordia", Azienda Sanitaria Universitaria Friuli Centrale, Udine

    Udine, Udine, 33100, Italy

  • Università degli Studi "Magna Grecia" di Catanzaro, Azienda Ospedaliero-Universitaria Renato Dulbecco

    Catanzaro, Catanzaro, 88100, Italy

  • Università di Cagliari, Dipartimento di Scienze Chirurgiche

    Cagliari, Cagliari, 09124, Italy

  • Università di Firenze, Ospedale Santa Maria Annunziata

    Florence, Firenze, 50012, Italy

  • Università di Milano, Ospedale Macedonio Melloni

    Milan, Milano, 20129, Italy

  • Università di Roma La Sapienza, Policlinico Umberto I

    Roma, Roma, 00161, Italy

  • Università di Roma Tor Vergata, Policlinico Tor Vergata

    Roma, Roma, 00133, Italy

  • Università di Siena, Policlinico Santa Maria alle Scotte

    Siena, Siena, 53100, Italy

  • Università di Verona, Ospedale Borgo Roma

    Verona, Verona, 37126, Italy

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