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Worldwide infection study aims to unlock secrets of acute illness

NCT ID NCT07069400

Knowledge-focused Sponsor: University of Minnesota Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Aug 28, 2026 · Updated 6 times

Summary

This observational study will enroll 1,500 adults hospitalized with acute infections across the globe. Researchers will collect medical data and biological samples to better understand how these infections progress, what factors affect recovery, and how to design better clinical trials in the future. The study does not test any new drug or treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors better understand acute infections and design more effective treatments and clinical trials for future outbreaks.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly test any new drug or therapy. Results may take years to influence patient care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,500 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants will be enrolled at study sites globally. Study personnel at the enrolling site will confirm eligibility and obtain consent prior to beginning study procedures. Signing of the informed consent document signifies study entry and Study Day 0. The study population includes adult patients admitted to a hospital with a suspected or confirmed acute infection. All participants will meet the eligibility criteria below. Specific studies executed with this master protocol may narrow the eligibility criteria to a more specific population (that is, a subset of patients who meet the eligibility criteria in this overarching protocol).

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years old * Admitted to hospital (or in an emergency department with anticipated hospital admission) for the management of a suspected or confirmed acute infectious disease. * Onset of symptoms of an infectious disease within the past 30 days. * Informed consent for study participation by the participant or a surrogate decision maker if the participant lacks capacity for consent. Exclusion Criteria: * Current imprisonment (this does not include quarantine for an infectious disease). * Patient undergoing comfort care measures only such that treatment focuses on end- of-life symptom management over prolongation of life. * Expected inability or unwillingness to participate in study procedures. * In the opinion of the investigator, participation in the study is not in the best interest of the patient.

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Get notified about this study

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Conditions

The condition(s) this trial relates to.

infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Infectious disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    56 sites in 21 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • 3rd Dept of Medicine, Medical School (Site 635-022)

    RECRUITING

    Athens, Attica, 11527, Greece

  • Associaco Beneficente Siria - HCor (649-203)

    RECRUITING

    São Paulo, São Paulo, 04004-030, Brazil

  • Austin Health (Site 612-020)

    RECRUITING

    Heidelberg, Victoria, 3084, Australia

  • Banner University Medical Center Tucson

    RECRUITING

    Tucson, Arizona, 85719, United States

  • CERMIPA (Site 403-001)

    RECRUITING

    Abidjan, Côte d’Ivoire

  • Central City Clinical Hospital of Ivano-Frankivsk City Council (627-302)

    RECRUITING

    Ivano-Frankivsk, 76018, Ukraine

  • Chulalongkorn University and The HIV-NAT (Site 613-001)

    RECRUITING

    Bangkok, 10330, Thailand

  • Cleveland Clinic Foundation (Site 207-001)

    RECRUITING

    Cleveland, Ohio, 44195, United States

  • Duke University (301-006)

    RECRUITING

    Durham, North Carolina, 27710, United States

  • Evangelismos General Hospital (Site 635-020)

    RECRUITING

    Athens, Attica, 10676, Greece

  • Fiona Stanley Hospital

    RECRUITING

    Murdoch, 6150, Australia

  • Fujita Health University Hospital

    RECRUITING

    Toyoake, Aichi-ken, 470-1192, Japan

  • Hospices Civiles de Lyon (631-033)

    RECRUITING

    Lyon, 69002, France

  • Hospital General de Agudos JM Ramos Mejia (Site 611-001)

    RECRUITING

    Buenos Aires, C1221ADC, Argentina

  • Hospital Nacional Guillermo Almenara Irigoyen (Site 651-003)

    RECRUITING

    Lima, 15033, Peru

  • Hospital St Louis (631-019)

    RECRUITING

    Paris, 75010, France

  • Hospital Universitari Germans Trias i Pujol (Site 626-003)

    RECRUITING

    Badalona, Barcelona, 08916, Spain

  • Instituto Medico Platense (611-025)

    RECRUITING

    La Plata, Buenos Aires, B1900AVG, Argentina

  • Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran (653-001)

    RECRUITING

    Mexico City, Mexico City, 14080, Mexico

  • Instituto Nacional de Entermadades Neoplasicas (Site 651-012

    RECRUITING

    Lima, 15038, Peru

  • Intermountain Medical Center (Site 211-001)

    RECRUITING

    Murray, Utah, 84107, United States

  • Japan Institute for Health Security

    RECRUITING

    Tokyo, 162-8655, Japan

  • Klinik I fur Innere Medizin der Universitat zu Koln (622-008)

    RECRUITING

    Cologne, 50937, Germany

  • Lira Regional Referral Hospital (Site 634-605)

    RECRUITING

    Lira, Uganda

  • Liverpool Hospital

    RECRUITING

    Liverpool, Australia

  • Lutheran Medical Group

    RECRUITING

    Fort Wayne, Indiana, 46804, United States

  • MEDVAMC (Site 074-006)

    RECRUITING

    Houston, Texas, 77030-4211, United States

  • MRC/UVRI & LSHTM Uganda Research Unit (Site 634-601)

    RECRUITING

    Entebbe, Uganda

  • Mayo Clinic (Site 054-001)

    RECRUITING

    Rochester, Minnesota, 55905, United States

  • Monash Health (612-009)

    RECRUITING

    Clayton, Victoria, 3168, Australia

  • Mount Sinai Medical Center (Site 301-012)

    RECRUITING

    New York, New York, 11234, United States

  • New York University Langone Health (301-013)

    RECRUITING

    New York, New York, 10016, United States

  • Orlando VA Medical Center (074-032)

    RECRUITING

    Orlando, Florida, 32827, United States

  • Parirenyatwa General Hospital

    RECRUITING

    Harare, Zimbabwe

  • Rigshospitalet, CHIP (625-006)

    RECRUITING

    Copenhagen, 2100, Denmark

  • Royal Brisbane and Women's Hospital (Site 612-055)

    RECRUITING

    Brisbane, Queensland, 4029, Australia

  • Royal Free Hospital (Site 634-006)

    RECRUITING

    London, NW3 2QG, United Kingdom

  • Royal Prince Alfred Hospital (612-056)

    RECRUITING

    Camperdown, New South Wales, 2050, Australia

  • SMIT du CHU de Donka

    RECRUITING

    Conakry, Guinea

  • Seoul National University Bundang Hospital

    RECRUITING

    Seongnam-si, Gyeonggi-do, 13620, South Korea

  • Seoul St. Mary's Hospital

    RECRUITING

    Seoul, 06591, South Korea

  • St. Vincent's Hospital (612-002)

    RECRUITING

    Sydney, New South Wales, 2010, Australia

  • Stanford University Hospital & Clinics (Site 203-003)

    RECRUITING

    Palo Alto, California, 94305, United States

  • Tan Tock Seng Hospital

    RECRUITING

    Singapore, 308443, Singapore

  • The Alfred Hospital (Site 612-017)

    RECRUITING

    Melbourne, Victoria, 3004, Australia

  • The Royal Melbourne Hospital (612-025)

    RECRUITING

    Parkville, Victoria, 3050, Australia

  • UCSF Medical Center (Site 203-001)

    RECRUITING

    San Francisco, California, 94143, United States

  • UT Southwestern Medical Center (084-001)

    RECRUITING

    Dallas, Texas, 75390, United States

  • University of Illinois at Chicago (Site 008-012)

    RECRUITING

    Chicago, Illinois, 60612, United States

  • University of Kansas Medical Center (Site 080-044)

    RECRUITING

    Kansas City, Kansas, 66160, United States

  • University of Minnesota

    NOT_YET_RECRUITING

    Minneapolis, Minnesota, 55414, United States

  • University of Nebraska Medical Center (Site 080-045)

    RECRUITING

    Omaha, Nebraska, 68198-5400, United States

  • Vanderbilt University Medical Center (Site 212-001)

    RECRUITING

    Nashville, Tennessee, 37232, United States

  • Wake Forest Baptist Health (210-001)

    RECRUITING

    Winston-Salem, North Carolina, 27157, United States

  • West Virginia University Medicine (301-023)

    RECRUITING

    Morgantown, West Virginia, 26506, United States

  • Westmead Hospital (Site 612-058)

    RECRUITING

    Westmead, New South Wales, 2145, Australia

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Other studies related to the condition(s) this trial covers.